Results 101 to 110 of about 2,064,464 (296)

Effects of Infertility Insurance Mandates on Fertility [PDF]

Infertility currently affects over 6 million individuals in the United States. While most health insurance plans nationwide do not cover infertility diagnoses or treatments, to date fifteen states have enacted some form of infertility insurance mandate ...
Lucie Schmidt
core   +2 more sources

Redefining Male Factor Infertility: Toward a Novel Diagnostic and Therapeutic Classification- Preliminary Findings [PDF]

openBackground Male factor infertility (MFI) is estimated to contribute to 30-50% of cases of couple infertility. Although MFI impact on couple infertility is relevant, during infertility investigations it is often neglected or considered only through ...
MANETTI, MATILDA
core  

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Global, regional, and national prevalence and years lived with disability due to infertility, 1990–2021: Results from the Global Burden of Disease Study 2021

Chinese Medical Journal
. Background:. Infertility is a burdensome, often overlooked condition. This study aimed to investigate the global distribution and trends in the burden of infertility from 1990 to 2021. Methods:.
Rui Lin, Yuan Lin, Guangfu Jin, Qiufen Sun, Zhibin Hu, Yanjie Yin   +5 more
doaj   +1 more source

Chromatin packaging anomalies and DNA damage in human sperm: their possible implications in the treatment of male factor infertility.

, 1997
The paper illustrates the relationships between chromatin packaging anomalies and DNA damage in human sperm and their possible implications in the treatment of male factor ...
BIZZARO D., MANICARDI, Gian Carlo, BIANCHI P. G., BIANCHI U., SAKKAS D.   +4 more
core  

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

OUTCOME OF FOLLICLE-STIMULATING HORMONE (FSH) THERAPY IN MALE INFERTILITY

reservedBackground: Infertility affects 15-25% of couples globally and the male factor accounts for approximately 40-50% of the cases, presenting a significant challenge to reproductive health. Treatment options for male infertility are limited and often
MITEVA, TEODORA VENTSISLAVOVA
core  

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

The Genetic Landscape of Male Factor Infertility and Implications for Men’s Health and Future Generations

Uro
Infertility is a significant global health issue, affecting 8–12% of couples of reproductive age, with male factor infertility contributing to 30–50% of cases.
Kristian Black, Sofie Ølgaard, Amelia A. Khoei, Clara Glazer, Dana A. Ohl, Christian Fuglesang S. Jensen   +5 more
doaj   +1 more source