Results 121 to 130 of about 2,064,464 (296)

Does coenzyme Q10 improve semen quality and circulating testosterone level? a systematic review and meta-analysis of randomized controlled trials

Frontiers in Pharmacology
BackgroundSeminal oxidative stress has been shown to be a key factor in the development of male infertility. However, the benefits of infertility treatments with antioxidants such as coenzyme Q10 (CoQ10) remains controversial.ObjectivesThe aim of the ...
Tunmise M. Akhigbe, Tunmise M. Akhigbe, Fabrael B. Fidelis, Fabrael B. Fidelis, Adebayo O. Adekunle, Adebayo O. Adekunle, Victory J. Ashonibare, Victory J. Ashonibare, Bolaji A. Akorede, Bolaji A. Akorede, Mansur S. Shuaibu, Mansur S. Shuaibu, Suliat A. Hassan, Cecilia A. Adegbola, Cecilia A. Adegbola, Precious J. Ashonibare, Precious J. Ashonibare, Opeyemi M. Oladapo, Opeyemi M. Oladapo, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Adetomiwa E. Adeogun, Seun G. Bamidele, Seun G. Bamidele, Precious A. Oyedokun, Precious A. Oyedokun, Mungala Mukolokota, Mungala Mukolokota, Omotolani S. Kukoyi, Omotolani S. Kukoyi, Ayoola A. Oladipo, Ayoola A. Oladipo, Olayinka E. Adelowo, Olayinka E. Adelowo, Marvelous D. Akangbe, Marvelous D. Akangbe, Jennifer R. Hughes, Albert M. Ricken, Martine Culty, Maria C. W. Avellar, Roland E. Akhigbe, Roland E. Akhigbe   +41 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Male infertility [PDF]

, 2000
Entre 10 a 15% dos casais falham em ter filhos após um ano de intercursos sexuais não protegidos. Cerca de 50% das causas de infertilidade são de origem masculina. Como causa simples de infertilidade, alterações espermáticas são a condição mais freqüente.
Cunha Filho, João Sabino Lahorgue da, Freitas, Fernando Monteiro de, Facin, Andrea Cintra, Passos, Eduardo Pandolfi, Salazar, Cristiano Caetano, Souza, Carlos Augusto Bastos de   +5 more
core   +1 more source

Potential biomarker signatures in male infertility: integrative genomic analysis

Egyptian Journal of Medical Human Genetics
Background Studies have attributed 50% of infertility cases to male infertility, 15% of which is caused by idiopathic genetic factors. Currently, no specific biomarkers have been revealed for male infertility.
Devalina Junahar, Rinesia Dwiputri, Wirawan Adikusuma, Darmawi Darmawi, Afdal Afdal, Lalu Muhammad Irham, Suyanto Suyanto   +6 more
doaj   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Male Infertility [PDF]

Proceedings of the Royal Society of Medicine, 1966
M W, Bishop, J S, David, A, Messervy
openaire   +5 more sources

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Next-Generation Sequencing Infertility Panel in Turkey: First Results

Balkan Journal of Medical Genetics
Male infertility is a complex pathophysiological disorder. At least 2000 genes are implicated in the etiology of male infertility, making it a very complex genetic condition. In cases of male infertility, genetic testing using next-generation sequencing (
Ikbal Atli E, Yalcintepe S, Atli E, Demir S, Gurkan H   +4 more
doaj   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source