Results 151 to 160 of about 102,503 (241)

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Advanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang   +7 more
wiley   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Male Infertility

Annals of Saudi Medicine, 1991
openaire   +2 more sources

Adamts1 Exacerbates Post‐Myocardial Infarction Scar Formation via Mechanosensing of Integrin α8

Advanced Science, EarlyView.
Proposed mechanistic model of ADAMTS1‐ITGα8 mechanotransduction in post‐MI scar formation. Schematic illustration showing the mechanistic pathway by which endothelial cell (EC) derived Adamts1 regulates cardiac fibroblast activation through ITGα8‐mediated mechanotransduction following myocardial infarction (MI).
Chun‐Yan Kong, Zhen Guo, Yu‐Lan Ma, Ming‐Yu Wang, Hai‐Yang Ni, Pan Wang, Wen‐Jun Qiu, En‐Gui Wang, Zhou Li, Zheng Yang, Bo Shen, Qi‐Zhu Tang   +11 more
wiley   +1 more source

Neoeriocitrin Targeting Beclin1 Deubiquitination and Autophagy in Osteogenic Differentiation of Human Dental Pulp Stem Cells

Advanced Science, EarlyView.
Neoeriocitrin enhances osteogenesis in hDPSCs and bone regeneration by targeting Beclin1 to inhibit ubiquitination‐mediated degradation, thereby stabilizing Beclin1 and increasing its protein abundance to activate autophagy. Abstract Human dental pulp stem cells (hDPSCs) are dental‐derived mesenchymal stem cells with robust multipotent differentiation ...
Yu Wu, Haotian Liu, Qunyi Wang, Ting Zhang, Rixin Chen, Qiao Yuan, Xin Tong, Wenrong Yang, Yin Xiao, Fuhua Yan   +9 more
wiley   +1 more source

Negotiating Masculinity: How Infertility Impacts Hegemonic Masculinity [PDF]

, 2014
Burton, Myscha
core   +1 more source

Norepinephrine Induces Sertoli Cell Ferroptosis via Receptors Desensitization Causing Stress‐Related Male Reproductive Dysfunction

Advanced Science, EarlyView.
Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang, Shanfeng Gao, Xiaofan Xiong, Xin Liu, Rufeng Li, Xia Wang, Lin Han, Xuan Xiao, Xiaofei Wang, Wen Li, Yongxia Chang, Yuefeng Du, Juan Yang   +12 more
wiley   +1 more source

Additive Manufactured Magnetoelectric Wireless Retainer as the Periodontal Remodeler for Post‐Orthodontic Tissue Reconstruction and Relapse‐Inhibition

Advanced Science, EarlyView.
Orthodontic relapse persists as a 120‐year challenge, as traditional retainers fail to remodel tissue, causing lifelong dependence. This study demonstrates a flexible magnetoelectric retainer (FMOR) enabling wireless periodontal remodeling. FMOR cues shift periodontal ligament cell (PDLC) paracrine signaling, promoting M2 macrophages, osteogenic ...
Haoqi Lei, Jiwei Sun, Peng Chen, Li Hu, Xin Zhou, Shiqiang Gong, Qingming Tang, Xiaoqing Han, Lili Chen, Bin Su   +9 more
wiley   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source