Results 231 to 240 of about 2,064,464 (296)

Whole-Genome Sequencing Identifies Potentially Causative Variants in <i>SOX30</i>, <i>AKAP4</i>, and <i>RNF220</i> in Non-Obstructive Azoospermia. [PDF]

Int J Mol Sci
Ebrahimi Askari R, Malcher A, Sefid F, Sadeghzadeh S, Ibrahim R, Pastuszak K, Srivastava A, Mehdi Kalantar S, Vahidi S, Ghasemi N, Kurpisz M.   +10 more
europepmc   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Clinical and Sociodemographic Profile of Patients Attending a Public Assisted Reproduction Unit and Factors Associated with the Type of Technique Used. [PDF]

Healthcare (Basel)
Martín Román LI, Cerezo Mondragón A, Gallardo Carvajal A, Cohen Corcia I, Blasco Alonso M, Jimenez Lopez JS.   +5 more
europepmc   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Sperm DNA fragmentation and its impact on pregnancy outcomes: a narrative review focusing on threshold definition and clinical strategies. [PDF]

Transl Androl Urol
Cheng S, Yuan Y, Wang Z, Xie Z, Chen Q, Liu Z, Chen Y, Song T, Yan M, Zheng Z, Lin H.   +10 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in gonadotropin-stimulated intrauterine insemination cycles for unexplained infertility: a retrospective cohort study. [PDF]

Ann Saudi Med
Efe MA, Dural O, Ulusoy HE, Aytekin AM, Akgül C.   +4 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

<i>HIPK4</i> is a novel gene associated with teratozoospermia and male infertility. [PDF]

Hum Reprod Open
Koser SA, Rieck C, Aprea I, Krallmann C, Gaikwad AS, Wallmeier J, Tenardi-Wenge R, Di Persio S, Neuhaus N, Raidt J, Omran H, Laurentino S, Kliesch S, Stallmeyer B, Friedrich C, Tüttelmann F.   +15 more
europepmc   +1 more source

Out-of-pocket expenditure experienced by couples seeking In Vitro Fertilization (IVF) services at tertiary care facilities in India. [PDF]

PLoS One
Patil P, Vikani A, Sharma D, Sachin O, Soman B, Bagepally BS, Tanwar R, Suri V, Radha V, Anitha M, Ramesh P, Shrivastava D, Patel S, Prinja S, Joshi B, IVF Project Team.   +15 more
europepmc   +1 more source