Results 41 to 50 of about 800,258 (219)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Land-use change effect on the hydro-dynamic characteristics of soil in the Brazilian semi-arid region

Revista Ambiente & Água, 2020
The search for better living conditions has led the residents of the Brazilian semi-arid region to plant forage crops, leading to a gradual decrease in the native vegetation (Caatinga) of this region.
Willames Albuquerque Soares, Simone Rosa da Silva, José Romualdo de Sousa Lima   +2 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Mechanism insight into twin-dependent photocatalysis in near-infrared light-responsive Cu2O nanocrystals with rich oxygen vacancies

Nano Materials Science
Simultaneous integration of rich oxygen vacancies (OVs) and twin crystals in a photocatalyst can not only significantly enhance the near-infrared (NIR) light response but also greatly improve the photocharge separation and transfer efficiency owing to ...
Xiaochuan Zhang, Shaodong Sun, Haotian Wang, Jieli Lyu, Xiaojing Yu, Bian Yang, Man Yang, Zongfan Duan, Qing Yang, Jie Cui   +9 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A novel method enabling in-situ additive manufactured TiB2/Cu composite with high performance

Journal of Materials Research and Technology
In-situ additive manufacturing method utilizes the high cooling rate of melt pool to produce composite parts with nano-scaled reinforcement and high relative density.
Yanfang Wang, Chengen Wang, Chengyu Ma, Shikui Huang, Kun Sheng, Siying Wang, Fei Cao, Yihui Jiang, Shuhua Liang   +8 more
doaj   +1 more source

INFILTRASI DAN SIMPANAN AIR PADA JENIS NAUNGAN YANG BERBEDA DI LAHAN KOPI DESA AMADANOM KECAMATAN DAMPIT KABUPATEN MALANG

JTSL (Jurnal Tanah dan Sumberdaya Lahan), 2019
Coffee plants belong to important commodities in Indonesia. In 2003, coffee productivity in Indonesia reached 725 kg ha-1 and decreased 0.41% in 2016 to 722 kg ha-1. Climate change is expected on the production of coffee crops.
Ika Lestiana Sari, Sugeng Prijono
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ga Doping Enables Precision Alloy‐to‐Wire Regulation: Synergistic Enhancement of the Mechanical Properties of CuSn Alloy and the Superconducting Properties of Nb3Sn

Advanced Science
Cu–Sn alloy is a key raw material used in the preparation of Nb3Sn superconducting wires using the bronze method. The mechanical properties of this Cu–Sn alloy are directly responsible for determining the properties of the superconducting wires.
Dazhuo Song, Juntao Zou, Jiayue Zhang, Xinhang Liang, Mengyu Shan, Yifan Liu, Jingqi Feng, Tong Dang, Lin Shi, Yuxuan Wang, Yuchen Song, Rong Fei, Shaodong Sun, Zhe Zhang, Lei Zhu, Lixing Sun   +15 more
doaj   +1 more source

Application of the electrical impedance spectrometry method for monitoring of water flow through unsaturated soil

Acta Scientiarum Polonorum. Formatio Circumiectus, 2020
Aim of the study: The aim of the research was to determine the sensitivity of the impedance spectrometry (EIS) method to changes in electrical resistance of the soil medium caused by water infiltration. Material and methods: The research was carried
Tymoteusz Adam Zydroń, Andrzej Gruchot , Jana Pařílková, Zbyněk Zachoval   +3 more
doaj   +1 more source