Results 51 to 60 of about 770,029 (237)

Impact of overland flow on soil characteristics in Třebsín experimental plots

Soil and Water Research, 2017
This paper describes the continuation of simulated outcomes from the plots No. 4 and No. 5 with two different soils, using the KINFIL model to assess the runoff from extreme rainfall. The KINFIL model is a physically-based, parameter-distributed 3D model
Hana BAČINOVÁ, Pavel KOVÁŘ
doaj   +1 more source

Evaluation of Beerkan Infiltration Method in Estimation of Saturated Hydraulic Conductivity of Soil [PDF]

علوم و مهندسی آبیاری, 2017
Determination of the field-saturated hydraulic conductivity can result in very high variability. So, analysis and simulation of hydrological processes such as runoff from rain requires a lot of data of field-saturated hydraulic conductivity even on a ...
Mahdi Keikha, Meysam Amiri, Mohsen Farahi   +2 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Supramolecular self-assembled graphitic carbon nitride catalyst: A comprehensive review on design principle, synthesis strategy, functionalization and application

Nano Materials Science
Graphitic carbon nitride (g-CN) stands out as the most promising candidate for solar energy conversion owing to its easy preparation, metal-free nature, flexible molecular structure, moderate bandgap, and excellent thermal/chemical stability.
Hao Yang, Shaodong Sun, Qing Yang, Jie Cui   +3 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Laser directed energy deposition of Cu-Cr-Zr alloy: Microstructure evolution and its influence on properties

Materials & Design
Laser directed energy deposited (L-DEDed) Cu alloys present substantial advantages for manufacturing thermal management devices without potential constraints on size.
Yanfang Wang, Chengyu Ma, Yufan Zhao, Gaoyuan Wang, Jiaqiang Li, Wenjun Ma, Yihui Jiang, Shuhua Liang   +7 more
doaj   +1 more source

Removal of Different Kinds of Heavy Metals by Novel PPG-nZVI Beads and Their Application in Simulated Stormwater Infiltration Facility

Applied Sciences, 2019
Polyvinyl alcohol and pumice synthetized guar gum-nanoscale zerovalent iron beads (PPG-nZVI beads) were synthesized, and their adsorption towards Pb2+, Cu2+, and Zn2+ ions was evaluated. The adsorption kinetics of metal ions was well fitted by the pseudo-
Xiaoran Zhang, Lei Yan, Junfeng Liu, Ziyang Zhang, Chaohong Tan   +4 more
doaj   +1 more source