Results 251 to 260 of about 20,063 (303)

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Mechanically Robust Biodegradable Stents With Theragenerative Vascular Responses via Combined 3D Printing and Janus Nanoengineering

Advanced Science, EarlyView.
This work introduces a theragenerative 3D‐printed biodegradable stent with Janus nanoarchitecture for spatially controlled vascular healing. A luminal tantalum ion–implanted surface accelerates endothelialization and hemocompatibility, while an abluminal sirolimus/poly‐L‐lactic acid–tantalum layer provides sustained drug release and suppresses smooth ...
Jong Hwa Seo, Dong‐Sung Won, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Chan Ho Moon, Ji Won Kim, Yubeen Park, Minho Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo‐Hong Lee, Tae‐Sik Jang, Seokbeom Kim, Jun‐Kyu Park, Jung‐Hoon Park, Hyun‐Do Jung   +19 more
wiley   +1 more source

Sarcoid aortitis presenting as an ascending aortic mass mimicking intramural haematoma and complicated by retrograde aortic dissection: a case report. [PDF]

Eur Heart J Case Rep
Shehata MS, Elagha A.
europepmc   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source

Concomitant Cardiac Transthyretin Amyloidosis and Coronary Artery Disease---Imaging Features and Pitfalls. [PDF]

CJC Open
Lavoie N, Idrissi O, Ternacle J, O'Connor K, Powers A, Jacquier A, Morin F, Tessier M, Cieza T, Paradis JM, Bedard É, Marzouk M, Beaudoin J, Coté N, Bernier M, Pibarot P, Clavel MA, Salaun E.   +17 more
europepmc   +1 more source

Primary prevention implantable cardioverter-defibrillator therapy in non-ischaemic heart failure with reduced left ventricular ejection fraction: a European Heart Rhythm Association survey. [PDF]

Europace
Brociek E, Karvonen J, Mills MT, Ruwald MH, Migliore F, Conte G, Roten L, Futyma P, Marcantoni L, Mazurek M, Sultan A, Duray GZ, Perrotta L, Chun JKR.   +13 more
europepmc   +1 more source

Ocular squamous cell carcinoma (OSCC) in a female buffalo. [PDF]

Vet Med (Praha)
Viana RB, Lima AAB, de Sousa Soares JM, Borges GM, Marques DA, da Silva Lobato SM, de Menezes Melo D, Santos JCM, Bremgarter LDS, Zezema PE, da Gama Barbosa Monger S, Dos Santos GMA, Teixeira PPM, Galvao GR, Filho JDR, Monteiro BM.   +15 more
europepmc   +1 more source