Results 271 to 280 of about 20,063 (303)

Human Heart–Infiltrating T-Cell Clones From Rheumatic Heart Disease Patients Recognize Both Streptococcal and Cardiac Proteins

Circulation, 1995
Background β-Hemolytic streptococcal infection in developing countries still causes thousands of cases of rheumatic heart disease, demanding surgical valve correction. Antigenic mimicry between self and streptococcal components has been proposed as the triggering factor leading to autoimmunity in individuals with genetic ...
L. Guilherme, E. Cunha-Neto, V. Coelho, R. Snitcowsky, P. M. A. Pomerantzeff, R. V. Assis, F. Pedra, J. Neumann, A. Goldberg, M. E. Patarroyo, F. Pileggi, J. Kalil   +11 more
openaire   +2 more sources

Heart infiltrating T cell clones from a rheumatic heart disease patient display a common TCR usage and a degenerate antigen recognition pattern

Molecular Immunology, 2004
CD4+ T cells are most likely the ultimate effectors of chronic heart lesions in rheumatic heart disease (RHD). We have demonstrated that infiltrating CD4+ T cell clones were able to recognize several heart tissue and streptococcal antigens by molecular mimicry.
K, Faé, J, Kalil, A, Toubert, L, Guilherme   +3 more
openaire   +2 more sources

Restriction in the Usage of Variable β Regions in T-cells Infiltrating Valvular Tissue from Rheumatic Heart Disease Patients

Journal of Autoimmunity, 2002
Rheumatic Heart Disease (RHD) is a delayed consequence of a pharyngeal infection with group A streptococcus (GAS), usually ascribed to a cross-reactive immune response to the host's cardiac tissues. Several GAS proteins have been reported to be superantigens, also raising the possibility that T cells in RHD could be driven by superantigens.
F, Figueroa, M, González, F, Carrión, C, Lobos, F, Turner, N, Lasagna, F, Valdés   +6 more
openaire   +2 more sources

FRI0139 Inflammatory cell infiltrates in the heart of patients with coronary artery disease with and without inflammatory rheumatic disease: a biopsy study.

Annals of the Rheumatic Diseases, 2013
Background Systemic rheumatic diseases (SRDs) are associated with increased cardiovascular (CV) morbidity due to accelerated atherosclerosis. However, SRDs are also associated with cardiac vasculitis that may contribute to the increased CV risk. In the Feiring Heart Biopsy Study (FHBS) a high occurrence of inflammatory cell infiltrates (ICI) in the ...
J.K. Andersen, I.L. Kvelstad, K. Mikkelsen, I. Oma, T. Veel, S.M. Almdahl, M.H. Liang, T.Ø. Førre, M.W. Fagerland, I. Hollan   +9 more
openaire   +1 more source

Immunohistochemical characterisation of Aschoff nodules and endomyocardial inflammatory infiltrates in left atrial appendages from patients with chronic rheumatic heart disease

International Journal of Cardiology, 1988
Fifty left atrial appendages collected fresh during closed mitral valvotomy in patients with chronic rheumatic heart disease, were analysed to determine the frequency of Aschoff nodules and characteristics of mononuclear inflammatory infiltration. Fifty-six percent of specimens demonstrated Aschoff nodules with no clinical or laboratory evidence of ...
P, Chopra, J, Narula, A S, Kumar, S, Sachdeva, M L, Bhatia   +4 more
openaire   +2 more sources

ORIGIN AND MODERN CLINICAL DIAGNOSIS OF INFILTRATIVE HEART DISEASES

To date, nine amyloidogenic proteins have been identified that can accumulate in the myocardium and cause cardiac amyloidosis. Three of them are common: serum amyloid A (AA amyloidosis, a consequence of chronic inflammation and infectious diseases), immunoglobulin light chains (AL amyloidosis, a consequence of monoclonal gammopathy), and transthyretin (
¹Ergashev Davlat, ²Xolmatov Mehroj, ³Boltayev Husan, ⁴Mardonqulov Akmal, ⁵Yavg'ashev Asomiddin   +4 more
openaire   +1 more source

The patient with heart failure and infiltrative cardiac disease

Abstract Conditions that result in the abnormal deposition of substances within cardiac myocytes or in the myocardial interstitium can be classed as infiltrative cardiomyopathies. The presentation of infiltrative cardiomyopathy can be non-specific but include heart failure and heart rhythm disorders. It is common for misclassification
Roy S. Gardner, Theresa A. McDonagh, Daniel J. Doherty, Nikki L. Walker   +3 more
openaire   +1 more source

USE OF MULTI-MODALITY IMAGING IN DETERMINING THE ETIOLOGY OF COMBINED SYSTOLIC AND DIASTOLIC HEART FAILURE IN THE ELDERLY WITH VALVULAR HEART DISEASE AND INFILTRATIVE CARDIOMYOPATHY

Journal of the American College of Cardiology, 2019
Transthyretin type cardiac amyloidosis (ATTR-CA) is prevalent in ~16% of the elderly with severe calcific aortic valve stenosis (AoS) being considered for TAVR. Tc-99m PYP cardiac imaging is useful in identifying ATTR-CA in these patients.
Anthony Ea, Douglas Rheam, Renee Bullock-Palmer   +2 more
openaire   +1 more source

The relationship of nodular endocardial infiltrates (Quilty lesions) to survival, patient age, anti-HLA antibodies, and coronary artery disease following heart transplantation

Cardiovascular Pathology, 2005
Quilty lesions are mononuclear cell infiltrates identified in human heart transplant biopsies. The biologic significance of Quilty lesions remains undetermined.We monitored acute rejection by biopsy and lymphocyte growth assay (LGA) as well as transplant-related coronary artery disease (TRCAD) by yearly angiogram in 285 recipients of primary heart ...
Kimberly E, Chu, Eric K, Ho, Ludwika, de la Torre, Elena R, Vasilescu, Charles C, Marboe   +4 more
openaire   +2 more sources

PDIA3, HSPA5 and vimentin, proteins identified by 2-DE in the valvular tissue, are the target antigens of peripheral and heart infiltrating T cells from chronic rheumatic heart disease patients

Journal of Autoimmunity, 2008
Rheumatic fever (RF) is a post-infectious autoimmune disease due to sequel of group A streptococcus (GAS) pharyngitis. Rheumatic heart disease (RHD), the major manifestation of RF, is characterized by inflammation of heart valves and myocardium. Molecular mimicry between GAS antigens and host proteins has been shown at B and T cell level.
Kellen C, Faé, Danielle, Diefenbach da Silva, Angelina M B, Bilate, Ana C, Tanaka, Pablo M A, Pomerantzeff, Maria Helena, Kiss, Clovis A A, Silva, Edecio, Cunha-Neto, Jorge, Kalil, Luiza, Guilherme   +9 more
openaire   +2 more sources