Results 81 to 90 of about 31,317 (308)

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]

, 2014
G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin, Ivan, Michael E, Kaur, Gurvinder, Oh, Michael C, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +8 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion. [PDF]

, 2018
Organoid methodology provides a platform for the ex vivo investigation of the cellular and molecular mechanisms underlying brain development and disease.
da Silva, B, Mathew, RK, Polson, ES, Williams, J, Wurdak, H   +4 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells [PDF]

, 2013
As inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the second mitochondrial activator of caspases (Smac) mimetic BV6, which antagonizes IAP proteins, on non-apoptotic ...
Eckhardt, Ines, Fulda, Simone, Jennewein, Carla, Rajalingam, Krishnaraj, Tchoghandjian, Aurélie   +4 more
core   +3 more sources

Massive Infiltrative Osteolysis of the Mandible in Oral Squamous Cell Carcinoma: A Case Report with a Review of the Literature

Precision Radiation Oncology
Oral Squamous Cell Carcinoma (OSCC) is the most prevalent form of oral cancer, constituting over 90% of reported cases. This malignancy commonly infiltrates bone, making bone invasion a significant clinical issue.
Smrithy Sivadas K, Ananya Madiyal, Vidya Ajila, Krishna Sharan, Yashika Jain   +4 more
doaj   +1 more source

Infiltrative Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis Treated With a Single High-Dose Y90 Radioembolization and Subsequent Liver Transplantation Without a Recurrence

Transplantation Direct, 2017
Background. Infiltrative hepatocellular carcinoma with macrovascular invasion is a relatively rare presentation and usually fatal disease. Methods. Both patients exceeded Milan and University of California-San Francisco (UCSF) criteria, and per Barcelona
Meaghan S. Dendy, MD, Juan C. Camacho, MD, Johannes M. Ludwig, MD, Alyssa M. Krasinskas, MD, Stuart J. Knechtle, MD, Hyun S. Kim, MD   +5 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Update on rare epithelial ovarian cancers: based on the Rare Ovarian Tumors Young Investigator Conference [PDF]

, 2017
There has been significant progress in the understanding of the pathology and molecular biology of rare ovarian cancers, which has helped both diagnosis and treatment.
Bookman, M, Iida, Y, Jang, JYA, Kaku, T, Kawabata, A, Kim, BG, Kim, JW, Kiyokawa, T, Kuroda, T, Ledermann, J, Matsumura, N, Mikami, Y, Nagayoshi, Y, Oda, K, Okamoto, A, Pujade-Lauraine, E, Quinn, M, Shimada, M, Yanaihara, N   +18 more
core   +2 more sources

Aggressive primary thyroid lymphoma: imaging features of two elderly patients [PDF]

Ultrasonography, 2014
<p>We report two cases of aggressive thyroid lymphoma in elderly patients that presented as Epub ahead of print large infiltrative thyroid masses with extensive invasion to adjacent structures including trachea, esophagus, and common ...
Eu Hyun Kim, JeeYoung Kim, Tae-Jung Kim
doaj   +1 more source