Results 71 to 80 of about 262,466 (282)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The permanence and periodic solution of a competitive system with infinite delay, feedback control, and Allee effect

open access: yesAdvances in Difference Equations, 2018
This paper is devoted to study the permanence and periodic solution of a competitive system with infinite delay, feedback control, and the Allee effect.
Lei Shi   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Multivalued evolution equations with infinite delay in Fréchet spaces

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 2008
In this paper, sufficient conditions are given to investigate the existence of mild solutions on a semi-infinite interval for two classes of first order semilinear functional and neutral functional differential evolution inclusions with infinite delay ...
Selma BAGHLI-BENDIMERAD   +1 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Dynamic of a nonautonomous two-species impulsive competitive system with infinite delays

open access: yesOpen Mathematics, 2019
In this paper, we consider a nonautonomous two-species impulsive competitive system with infinite delays. By the impulsive comparison theorem and some mathematical analysis, we investigate the permanence, extinction and global attractivity of the system,
He Mengxin, Li Zhong, Chen Fengde
doaj   +1 more source

Bohl-Perron type stability theorems for linear difference equations with infinite delay

open access: yes, 2010
Relation between two properties of linear difference equations with infinite delay is investigated: (i) exponential stability, (ii) $\l^p$-input $\l^q$-state stability (sometimes is called Perron's property).
Berezansky L.   +8 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Permanence of predator-prey system with infinite delay

open access: yesElectronic Journal of Differential Equations, 2004
In this paper we consider a predator-prey system with periodic coefficients and infinite delay, in which the prey has a history that takes them through two stages, immature and mature.
Jingan Cui, Yonghong Sun
doaj  

Waveguide QED: Power Spectra and Correlations of Two Photons Scattered Off Multiple Distant Qubits and a Mirror

open access: yes, 2015
We study two-level systems (2LS) coupled at different points to a one-dimensional waveguide in which one end is open and the other is either open (infinite waveguide) or closed by a mirror (semi-infinite).
Baranger, Harold U., Fang, Yao-Lung L.
core   +1 more source

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