Results 51 to 60 of about 23,117 (284)

Qualitative analysis of Volterra-type integral equations with an infinite delay model in spaces of locally bounded κ-variation functions

open access: yesArab Journal of Basic and Applied Sciences
Integral equations with memory effects and infinite delay arise naturally in applications such as ecology, neuroscience, and viscoelasticity, among others.
Luz Marchan   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Global convergence of successive approximations of the Darboux problem for partial functional differential equations with infinite delay [PDF]

open access: yesOpuscula Mathematica, 2014
We consider the Darboux problem for the hyperbolic partial functional differential equation with infinite delay. We deal with generalized (in the "almost everywhere" sense) solutions of this problem.
Tomasz Człapiński
doaj   +1 more source

Infinite–Dimensional Bifurcations in Spatially Distributed Delay Logistic Equation

open access: yesMathematics, 2022
This paper investigates the questions about the local dynamics in the neighborhood of the equilibrium state for the spatially distributed delay logistic equation with diffusion. The critical cases in the stability problem are singled out.
Sergey Kashchenko
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Marachkov type stability results for functional differential equations

open access: yesElectronic Journal of Qualitative Theory of Differential Equations, 1998
This paper is concerned with systems of functional differential equations with either finite or infinite delay. We give conditions on the system and on a Liapunov function to ensure that the zero solution is asymptotically stable. The main result of this
Theodore Burton, Géza Makay
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Stochastically Globally Exponential Stability of Stochastic Impulsive Differential Systems with Discrete and Infinite Distributed Delays Based on Vector Lyapunov Function

open access: yesComplexity, 2020
This paper deals with stochastically globally exponential stability (SGES) for stochastic impulsive differential systems (SIDSs) with discrete delays (DDs) and infinite distributed delays (IDDs).
Xiaoyan Liu, Quanxin Zhu
doaj   +1 more source

Semigroups on Frechet spaces and equations with infinite delays [PDF]

open access: yesProceedings Mathematical Sciences, 2007
In this paper, we show existence and uniqueness of a solution to a functional differential equation with infinite delay. We choose an appropriate Frechet space so as to cover a large class of functions to be used as initial functions to obtain existence and uniqueness of solutions.
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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