Results 51 to 60 of about 1,327,272 (305)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Topological Infinite Gammoids, and a New Menger-Type Theorem for Infinite Graphs [PDF]
Electronic Journal of Combinatorics, 2014 Answering a question of Diestel, we develop a topological notion of gammoids in infinite graphs which, unlike traditional infinite gammoids, always define a matroid.As our main tool, we prove for any infinite graph $G$ with vertex-sets $A$ and $B$, if ...
J. Carmesin
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Subshifts on Infinite Alphabets and Their Entropy
Entropy, 2020 We analyze symbolic dynamics to infinite alphabets by endowing the alphabet with the cofinite topology. The topological entropy is shown to be equal to the supremum of the growth rate of the complexity function with respect to finite subalphabets.
Sharwin Rezagholi
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Every infinitely edge-connected graph contains the Farey graph or $${T_{\aleph _0}*t}$$ as a minor [PDF]
, 2021 Jan Kurkofka
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Reachability Analysis of Reversal-bounded Automata on Series-Parallel Graphs [PDF]
Electronic Proceedings in Theoretical Computer Science, 2015 Extensions to finite-state automata on strings, such as multi-head automata or multi-counter automata, have been successfully used to encode many infinite-state non-regular verification problems.
Rayna Dimitrova, Rupak Majumdar
doaj +1 more source
The Distinguishing Index of Infinite Graphs
Electronic Journal of Combinatorics, 2015 The distinguishing index $D^\prime(G)$ of a graph $G$ is the least cardinal $d$ such that $G$ has an edge colouring with $d$ colours that is only preserved by the trivial automorphism. This is similar to the notion of the distinguishing number $D(G)$ of
I. Broere, M. Pilsniak
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source