Results 51 to 60 of about 279,078 (329)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Subshifts on Infinite Alphabets and Their Entropy
Entropy, 2020 We analyze symbolic dynamics to infinite alphabets by endowing the alphabet with the cofinite topology. The topological entropy is shown to be equal to the supremum of the growth rate of the complexity function with respect to finite subalphabets.
Sharwin Rezagholi
doaj +1 more source
Resolvent of Large Random Graphs
, 2009 We analyze the convergence of the spectrum of large random graphs to the spectrum of a limit infinite graph. We apply these results to graphs converging locally to trees and derive a new formula for the Stieljes transform of the spectral measure of such ...
Aldous +31 more
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Pair L(2, 1)-Labelings of Infinite Graphs
Discussiones Mathematicae Graph Theory, 2019 An L(2, 1)-labeling of a graph G = (V,E) is an assignment of nonnegative integers to V such that two adjacent vertices must receive numbers (labels) at least two apart and further, if two vertices are in distance 2 then they receive distinct labels. This
Yeh Roger K.
doaj +1 more source
Reachability Analysis of Reversal-bounded Automata on Series-Parallel Graphs [PDF]
Electronic Proceedings in Theoretical Computer Science, 2015 Extensions to finite-state automata on strings, such as multi-head automata or multi-counter automata, have been successfully used to encode many infinite-state non-regular verification problems.
Rayna Dimitrova, Rupak Majumdar
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
On Laplacian Equienergetic Signed Graphs
Journal of Mathematics, 2021 The Laplacian energy of a signed graph is defined as the sum of the distance of its Laplacian eigenvalues from its average degree. Two signed graphs of the same order are said to be Laplacian equienergetic if their Laplacian energies are equal.
Qingyun Tao, Lixin Tao
doaj +1 more source