Results 71 to 80 of about 3,935,207 (294)

Existence and Nonexistence of Solutions to p-Laplacian Problems on Unbounded Domains

Mathematics, 2019
In this article, using a fixed point index theorem on a cone, we prove the existence and multiplicity results of positive solutions to a one-dimensional p-Laplacian problem defined on infinite intervals.
Jeongmi Jeong, Chan-Gyun Kim, Eun Kyoung Lee   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The Index of an Infinite Dimensional Implicit System [PDF]

Mathematical and Computer Modelling of Dynamical Systems, 1999
The idea of the index of a differential algebraic equation (DAE) (or implicit differential equation) has played a fundamental role in both the analysis of DAEs and the development of numerical algorithms for DAEs. DAEs frequently arise as partial discretizations of partial differential equations (PDEs). In order to relate properties of the PDE to those
S.L. Campbell, W. Marszalek
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Existence of infinitely many periodic subharmonic solutions for nonlinear non-autonomous neutral differential equations

Electronic Journal of Differential Equations, 2013
In this article, we study the existence of an infinite number of subharmonic periodic solutions to a class of second-order neutral nonlinear functional differential equations.
Xiao-Bao Shu, Yongzeng Lai, Fei Xu
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Finite and infinite element method applied to water wave diffraction problems [PDF]

, 1999
In this work, three types of infinite elements are developed to solve the problem of linear water wave diffraction by objects in a 2D unbounded domain. The infinite elements, which model the far field wave potential stretching to infinity, are coupled to
Baghbani, A., Baghbani, Alireza
core  

The Eccentricity Version of Atom-Bond Connectivity Index of Linear Polycene Parallelogram Benzenoid ABC5(P(n,n))

Acta Chimica Slovenica, 2016
Among topological descriptors, connectivity indices are very important and they have a prominent role in chemistry. The atom-bond connectivity index of a connected graph G is defined as ABC(G)= where dv denotes the degree of vertex v of G and the ...
Wei Gao, Mohammad Reza Farahani, Muhammad Kamran Jamil   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source