Results 81 to 90 of about 3,935,207 (294)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

A construction of semi-infinite de Rham cohomology [PDF]

open access: yes
The purpose of this thesis is to describe a construction of semi-infinite de Rham cohomology for infinite dimensional manifolds equipped with the extra structure of a polarisation.
Stacey, Andrew Edgell
core  

Infinite paths to infinite reality Sri Ramakrishna and cross-cultural philosophy of religion

open access: yes, 2018
"This pioneering study examines the philosophy of the nineteenth-century Indian mystic Sri Ramakrishna and brings him into dialogue with recent Western thinkers.
Maharaj, Ayon
core   +1 more source

New Green’s function and two infinite families of positive solutions for a second order impulsive singular parametric equation

open access: yesAdvances in Difference Equations, 2017
Using the theorem and properties of the fixed point index in a Banach space and applying a new method to dispose of the impulsive term, we prove that there exists a solvable interval of positive parameter λ in which the second order impulsive singular ...
Minmin Wang, Meiqiang Feng
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Infinite Universe and Dembski’s Design Inference [PDF]

open access: yes, 2004
Did God create life? Or did life arise via naturalistic processes, along the lines of random mutation and natural selection as suggested by Darwin?
Monton, Bradley
core  

PRIDICTION OF THE PRODUCTIVITY OF HYDRAULIC FRACTURED VERTICAL WELL WITH INFINITE CONDUCTIVITY FRACTURE

open access: yesИзвестия высших учебных заведений: Нефть и газ, 2017
Hydraulic fracturing is used to significantly improve well productivity, particularly in reservoirs with low permeability. In carrying out this operation in the reservoir creates a large branched system of cracks.
S. A. Faiq, A. V. Sarancha
doaj   +1 more source

Computing the Rabin Index of a Regular Language of Infinite Words

open access: yesInformation and Computation, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Thomas Wilke, Haiseung Yoo
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

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