Results 91 to 100 of about 498 (210)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Karush-Kuhn-Tucker Types Optimality Conditions for Non-Smooth Semi-Infinite Vector Optimization Problems

Journal of Mathematical Extension, 2015
In this paper we establish necessary and sufficient optimality conditions for a nondifferenriable, nonconvex semi-infinite vector optimization problem involving locally Lipschitz functions, whose constraints are required to depend continuously on an ...
N. Kanzi∗
doaj  

Chain Conditions for Subgroups of Infinite Order or Index

Journal of Algebra, 2002
Various weakened forms of the maximal condition on subgroups max and the minimal condition on subgroups min have been proposed, the best known being the weak maximal and minimal conditions of \textit{D. I. Zajtsev} [Dokl. Akad. Nauk. SSSR 178, 780-782 (1968; Zbl 0167.28803)].
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Eccentric Connectivity Index of t-Polyacenic Nanotubes

Advances in Materials Science and Engineering, 2019
The eccentric connectivity index ECI is a chemical structure descriptor that is currently being used for the modeling of biological activities of a chemical compound.
Jia-Bao Liu, Hani Shaker, Imran Nadeem, Mohammad Reza Farahani   +3 more
doaj   +1 more source

Unions of chains of subgroups of a topologucal group

Applied General Topology, 2001
We consider the following problem: If a topological group G is the union of an increasing chain of subgroups and certain cardinal invariants of the subgroups in the chain are known, what can be said about G?
Yolanda Torres Falcón
doaj   +1 more source

On the homotopy index for infinite-dimensional semiflows [PDF]

Transactions of the American Mathematical Society, 1982
In this paper we consider semiflows whose solution operator is eventually a conditional α \alpha
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Evaluating Large Language Models in Code Generation: INFINITE Methodology for Defining the Inference Index

Applied Sciences
This study introduces a new methodology for an Inference Index (InI) called the Inference Index In Testing Model Effectiveness methodology (INFINITE), aiming to evaluate the performance of Large Language Models (LLMs) in code generation tasks.
Nicholas Christakis, Dimitris Drikakis
doaj   +1 more source