Results 91 to 100 of about 3,935,207 (294)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Semisimple groups interpretable in various valued fields

Forum of Mathematics, Sigma
We study infinite groups interpretable in power bounded T-convex, V-minimal or p-adically closed fields. We show that if G is an interpretable definably semisimple group (i.e., has no definable infinite normal abelian subgroups) then, up to a finite ...
Yatir Halevi, Assaf Hasson, Ya'acov Peterzil   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Short Note on the Infinite Decision Puzzle [PDF]

This work draws on the Supertask literature1 in order to better understand the conceptual and physical possibility of an infinite decision puzzle presented by Barrett and Arntzenius (1999, 2002).
Garcia-Fronti, Javier
core  

Solvability conditions for some difference operators

Advances in Difference Equations, 2005
Infinite-dimensional difference operators are studied. Under the assumption that the coefficients of the operator have limits at infinity, limiting operators and associated polynomials are introduced.
Volpert VA, Apreutesei NC
doaj   +2 more sources

The dynamic properties of solutions for a nonlinear shallow water equation

Boundary Value Problems, 2019
The local well-posedness for the Cauchy problem of a nonlinear shallow water equation is established. The wave-breaking mechanisms, global existence, and infinite propagation speed of solutions to the equation are derived under certain assumptions.
Yeqin Su, Shaoyong Lai, Sen Ming
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Witten index of BMN matrix quantum mechanics

SciPost Physics
We compute the Witten index of the Berenstein-Maldacena-Nastase matrix quantum mechanics, which counts the number of ground states as well as the difference between the numbers of bosonic and fermionic BPS states with nonzero angular momenta.
Chi-Ming Chang
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Index theorems on open infinite manifolds

Nuclear Physics B, 1986
Abstract A new index theorem for Dirac operators defined on open infinite manifolds is derived. The derivation is based on the use of trace identifies and assumes the validity of the standard chiral anomaly equation. The theorem generalizes the Callias index theorem for arbitrary background fields and is analogous to the Atiyah-Patodi-Singer index ...
A.J. Niemi, G.W. Semenoff
openaire   +1 more source