Results 61 to 70 of about 4,468,594 (288)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Statistical convergence of infinite series [PDF]

open access: yes, 2001
summary:In this paper we use the notion of statistical convergence of infinite series naturally introduced as the statistical convergence of the sequence of the partial sums of the series.
Tibor Šalát   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

THE TRANS LEVEL CHARACTERISTICS ABOUT INFINITE SERIES

open access: yesJurnal Magister Pendidikan Matematika, 2019
Infinite series is one of the difficult calculus material for students. It needs to be analyzed the cognitive activities of students to make it easier for lecturers to arrange learning plans.
Wahyu Widada   +3 more
doaj   +1 more source

On Functions Preserving Convergence of Series in Fuzzy n-Normed Spaces [PDF]

open access: yes, 2009
The purpose of this paper is to introduce finite convergence sequences and functions preserving convergence of series in fuzzy n-normed ...
Rahmat, Mohamad Rafi Segi, Elagan, Sayed
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Variance changes detection in multivariate time series [PDF]

open access: yes, 2004
This paper studies the detection of step changes in the variances and in the correlation structure of the components of a vector of time series. Two procedures are considered.
Peña, Daniel   +3 more
core   +1 more source

Oscilador harmônico amortecido e séries infinitas

open access: yesRevista Brasileira de Ensino de Física
Neste trabalho discute-se um arranjo experimental bastante simples e de baixo custo, cujo objetivo consiste em se exemplificar de forma concreta a aplicação de técnicas matemáticas envolvendo solução por séries infinitas destinadas ao estudo de ...
Marcello G. Rodrigues   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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