Results 41 to 50 of about 4,468,594 (288)

Argument-forms which turn invalid over infinite domains: Physicalism as supertask? [PDF]

open access: yes, 2008
Argument-forms exist which are valid over finite but not infinite domains. Despite understanding of this by formal logicians, philosophers can be observed treating as valid arguments which are in fact invalid over infinite domains.
Legg, Catherine
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Some Pitfalls in Introductory Programming Courses

open access: yesInformatics in Education, 2012
This paper discusses some difficulties in teaching introductory courses to programming, paying particular attention to their mathematical nature. We consider some aspects, which have not been commented in detail in textbooks and often neglected by course
Teodosi TEODOSIEV, Anatoli NACHEV
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Two criteria for trascendental sequences

open access: yesLe Matematiche, 2001
The concept of trascendental sequence is defined in this contribution by means of the related trascendental series. The main results are two criteria for when certain sequences are trascendental. Several applications are presented.
Jaroslav Hančl
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Infinite Product Representation for the Szegö Kernel for an Annulus

open access: yesJournal of Function Spaces, 2022
The Szegö kernel has many applications to problems in conformal mapping and satisfies the Kerzman-Stein integral equation. The Szegö kernel for an annulus can be expressed as a bilateral series and has a unique zero.
Nuraddeen S. Gafai   +2 more
doaj   +1 more source

A software perspective on infinite elements for wave diffraction and wave forces on marine risers [PDF]

open access: yes, 2000
This thesis describes work on the problem of the scattering of water waves by fixed objects. The method used to solve this problem is that of finite and infinite elements. In particular the development of a new wave infinite element is described. Various
Bettess, J.A., Bettess, Jacqueline Anne
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

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