Results 331 to 340 of about 197,632 (380)

Repeated exposure to CoCr28Mo6 particles leads to activation of NLRP3 inflammasome signaling in human osteoblasts. [PDF]

Cell Biol Toxicol
Sellin ML, Koentopp LM, Bader R, Jonitz-Heincke A.   +3 more
europepmc   +1 more source

Astragaloside IV Alleviates Ulcerative Colitis Progression by Inhibiting WDR5‐Mediated ENO1 H3K4me3 Modification

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ulcerative colitis (UC) has become a prevalent global health concern. This study scrutinized the influence of Astragaloside IV (ASI) on DSS‐induced UC, with particular emphasis on the role of WDR5 in mediating ENO1 expression. The therapeutic efficacy of ASI was assessed in a mouse model of UC by evaluating disease activity index, pathology ...
Su‐Xiao Wu, Zi‐Lan Chen, Xiao‐Hong Wang, Jie Gu   +3 more
wiley   +1 more source

Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia. [PDF]

J Neuroimmune Pharmacol
Starr A, Rathore S, Daniali M, Gaskill PJ, Akay-Espinoza C, Jordan-Sciutto KL.   +5 more
europepmc   +1 more source

Regulatory Effect and Mechanism of Tanshinone I on Cell Apoptosis in Steroid‐Induced Osteonecrosis of the Femoral Head

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SIONFH) is a debilitating orthopedic condition. This study investigated the mechanism of Tanshinone I (TsI) in SIONFH modulating apoptosis in SIONFH via the PI3K/AKT/mTOR pathway. A SIONFH rat model was treated with TsI and a PI3K activator. Bone mineral density (BMD), bone volume/total volume
Qing Su, Jia Chen
wiley   +1 more source

Iron-Inflammasome Crosstalk in Adipose Tissue: Unresolved Roles of NLRP3 and IL-1β in Metabolic Inflammation. [PDF]

Int J Mol Sci
Aguree S.
europepmc   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis. [PDF]

Parasite Immunol
de Heleno Chagas de Carvalho C, Araujo Flores GV, Sandoval Pacheco CM, da Ribeiro da Matta VL, de Esteves de Morais C, Romiti R, Belda Júnior W, Dalastra Laurenti M.   +7 more
europepmc   +1 more source

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

NLRP3 Inflammasome Activation Restricts Viral Replication by Inducing Pyroptosis in Chicken HD11 Cells During Infectious Bronchitis Virus Infection. [PDF]

Biology (Basel)
Han X, Yang X, Yang X, Liu T, He W.
europepmc   +1 more source

P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders

Medicine Bulletin, EarlyView.
ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley   +1 more source