Results 1 to 10 of about 4,758,008 (341)

RETRACTION: ET-1 Promotes Differentiation of Periodontal Ligament Stem Cells Into Osteoblasts Through ETR, MAPK, and Wnt/β-Catenin Signaling Pathways Under Inflammatory Microenvironment [PDF]

Mediators of Inflammation
Mediators of Inflammation
doaj   +2 more sources

Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, 2021
Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes.
Huakan Zhao, Lei Wu, Guifang Yan, Yu Chen, Mingyue Zhou, Yongzhong Wu, Yongsheng Li   +6 more
semanticscholar   +1 more source

The trinity of COVID-19: immunity, inflammation and intervention

Nature reviews. Immunology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and ...
M. Tay, C. Poh, L. Rénia, P. MacAry, L. Ng   +4 more
semanticscholar   +1 more source

NF-κB signaling in inflammation

Signal Transduction and Targeted Therapy, 2017
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu, Lingyun Zhang, Donghyun Joo, Shao-Cong Sun   +3 more
semanticscholar   +1 more source

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Nature reviews. Immunology, 2020
The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in ...
M. Merad, Jérôme C. Martin
semanticscholar   +1 more source

Inflammation and aging: signaling pathways and intervention therapies

Signal Transduction and Targeted Therapy, 2023
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases.
Xia Li, Chentao Li, Wanying Zhang, Yanan Wang, P. Qian, He Huang   +5 more
semanticscholar   +1 more source

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Cell Death and Disease, 2023
The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues.
Lien Verboom, Christopher J. Anderson, Maude Jans, Ioanna Petta, Gillian Blancke, Arne Martens, Mozes Sze, Tino Hochepied, Kodi S. Ravichandran, Lars Vereecke, Geert van Loo   +10 more
doaj   +1 more source

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Scientific Reports, 2023
A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA ...
Karel F. A. Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Aegerter, Andy Wullaert, Tino Hochepied, Esther Hoste, Lieselotte Vande Walle, Mohamed Lamkanfi, Savvas N. Savvides, Dirk Elewaut, Bart N. Lambrecht, Geert van Loo   +17 more
doaj   +1 more source

Inflammatory responses and inflammation-associated diseases in organs

OncoTarget, 2015
Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas,
Linlin Chen, H. Deng, H. Cui, J. Fang, Z. Zuo, J. Deng, Yinglun Li, Xun Wang, Ling Zhao   +8 more
semanticscholar   +1 more source

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Cell Death and Disease, 2023
Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL and GSDMs drive PMP
Yves Dondelinger, Dario Priem, Jon Huyghe, Tom Delanghe, Peter Vandenabeele, Mathieu J. M. Bertrand   +5 more
doaj   +1 more source