Results 1 to 10 of about 3,278,287 (342)
Inflammation and tumor progression: signaling pathways and targeted intervention
Signal Transduction and Targeted Therapy, 2021 Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes.
Huakan Zhao +6 more
semanticscholar +1 more source
The trinity of COVID-19: immunity, inflammation and intervention
Nature reviews. Immunology, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and ...
M. Tay +4 more
semanticscholar +1 more source
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Nature reviews. Immunology, 2020 The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in ...
M. Merad, Jérôme C. Martin
semanticscholar +1 more source
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
Cell Death and Disease, 2023 The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues.
Lien Verboom +10 more
doaj +1 more source
NF-κB signaling in inflammation
Signal Transduction and Targeted Therapy, 2017 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu +3 more
semanticscholar +1 more source
Scientific Reports, 2023 A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA ...
Karel F. A. Van Damme +17 more
doaj +1 more source
Inflammation and aging: signaling pathways and intervention therapies
Signal Transduction and Targeted Therapy, 2023 Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases.
Xia Li +5 more
semanticscholar +1 more source
Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota
eLife, 2018 As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Eaton et al., 2015) that described how we intended to replicate selected experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the ...
B. Nixon +8 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL and GSDMs drive PMP
Yves Dondelinger +5 more
doaj +1 more source
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
Nature Communications, 2021 OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of ...
Esther Hoste +16 more
doaj +1 more source