Results 1 to 10 of about 2,967,484 (341)
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
Cell Death and Disease, 2023 The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues.
Lien Verboom +10 more
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Cell Death and Disease, 2023 Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL and GSDMs drive PMP
Yves Dondelinger +5 more
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Scientific Reports, 2023 A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA ...
Karel F. A. Van Damme +17 more
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OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
Nature Communications, 2021 OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of ...
Esther Hoste +16 more
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Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Journal of Neuroinflammation, 2023 Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present.
Wouter Claeys +10 more
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EJNMMI Research, 2021 Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the
Erik H. J. G. Aarntzen +10 more
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Acta Neuropathologica Communications, 2021 Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflammation plays a key role in both the initiation ...
Junhua Xie +10 more
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Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
Cell Death and Disease, 2021 RIPK3 was reported to play an important role in the protection against influenza A virus (IAV) in vivo. Here we show that the requirement of RIPK3 for protection against IAV infection in vivo is only apparent within a limited dose range of IAV challenge.
Teodora Oltean +7 more
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Biomedicines, 2022 Prostate cancer (PCa) is one of the most common cancer types in men and represents an increasing global problem due to the modern Western lifestyle. The signalling adapter protein CARD14 is specifically expressed in epithelial cells, where it has been ...
Domien Vanneste +9 more
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Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials
Journal of Immunology Research, 2022 Objective. To assess the clinical efficacy of flavonoid supplements on allergic diseases. Design. Systematic review. Data Sources. MEDLINE/PubMed, Scopus, Web of Science, and Embase databases were searched from inception to September 2021.
Poliana Guiomar de Almeida Brasiel +4 more
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