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Journal of the American Society of Hypertension, 2007 Inflammation of the vessel wall is involved in all stages of the course of atherothrombotic disease, from the development of early lesions to the occurrence of clinical events. Significant advances in recent years have largely improved our understanding of this phenomenon and of its influence not only on atherogenesis, but also on other intimately ...
Valentin, Fuster, Javier, Sanz
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OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
Cell Death and Disease, 2023 The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues.
Lien Verboom +10 more
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Cell Death and Disease, 2023 Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL and GSDMs drive PMP
Yves Dondelinger +5 more
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Nonresolving Inflammation [PDF]
Cell, 2010 Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosis can provoke inflammation. Nonetheless, multiple mechanisms normally ensure resolution. Cells like macrophages switch phenotypes, secreted molecules like reactive oxygen intermediates switch impact ...
Nathan, Carl, Ding, Aihao
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Scientific Reports, 2023 A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA ...
Karel F. A. Van Damme +17 more
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OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
Nature Communications, 2021 OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of ...
Esther Hoste +16 more
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Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes
Journal of Neuroinflammation, 2023 Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present.
Wouter Claeys +10 more
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Acta Neuropathologica Communications, 2021 Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid β (Aβ) and neurofibrillary tangles. The last decade, it became increasingly clear that neuroinflammation plays a key role in both the initiation ...
Junhua Xie +10 more
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EJNMMI Research, 2021 Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the
Erik H. J. G. Aarntzen +10 more
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Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2
The EMBO Journal, 2023 Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots +9 more
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