Results 1 to 10 of about 2,394,340 (295)

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

open access: yesCell Death and Disease, 2023
The intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues.
Lien Verboom   +10 more
doaj   +1 more source

Vascular inflammation [PDF]

open access: yesJournal of the American Society of Hypertension, 2007
Inflammation of the vessel wall is involved in all stages of the course of atherothrombotic disease, from the development of early lesions to the occurrence of clinical events. Significant advances in recent years have largely improved our understanding of this phenomenon and of its influence not only on atherogenesis, but also on other intimately ...
Valentin, Fuster, Javier, Sanz
openaire   +4 more sources

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

open access: yesScientific Reports, 2023
A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA ...
Karel F. A. Van Damme   +17 more
doaj   +1 more source

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

open access: yesCell Death and Disease, 2023
Plasma membrane permeabilization (PMP) is a defining feature of regulated necrosis. It allows the extracellular release of damage-associated molecular patterns (DAMPs) that trigger sterile inflammation. The pore forming molecules MLKL and GSDMs drive PMP
Yves Dondelinger   +5 more
doaj   +1 more source

Nonresolving Inflammation [PDF]

open access: yesCell, 2010
Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an inherent risk because inflammation can damage tissue and necrosis can provoke inflammation. Nonetheless, multiple mechanisms normally ensure resolution. Cells like macrophages switch phenotypes, secreted molecules like reactive oxygen intermediates switch impact ...
Nathan, Carl, Ding, Aihao
openaire   +2 more sources

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

open access: yesNature Communications, 2021
OTULIN is a deubiquitinase for linear ubiquitin chains. Here the authors show, using genetic mouse models and single-cell RNA-sequencing, that deficiency of OTULIN in keratinocytes causes skin inflammation and verrucous carcinoma via the induction of ...
Esther Hoste   +16 more
doaj   +1 more source

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

open access: yesJournal of Neuroinflammation, 2023
Hepatic encephalopathy (HE) is a common complication of liver cirrhosis, associated with high morbidity and mortality, for which no brain-targeted therapies exist at present.
Wouter Claeys   +10 more
doaj   +1 more source

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