Results 101 to 110 of about 4,758,008 (341)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation [PDF]

, 2022
Yilin Sun, Shengbao Cai, Yuanyue Zhang, Nan Ma, Junjie Yi, Xiao Hu, Tao Wang   +6 more
openalex   +1 more source

Lactoferrin Decreases the Intestinal Inflammation Triggered by a Soybean Meal-Based Diet in Zebrafish [PDF]

, 2016
Indexación: Web of ScienceIntestinal inflammation is a harmful condition in fish that can be triggered by the ingestion of soybean meal. Due to the positive costs-benefits ratio of including soybean meal in farmed fish diets, identifying additives with ...
Alaurent, Trevor G. S., Caruffo, Mario, Dantagnan, Patricio, De la Paz, Javiera F., Feijóo, Carmen G., Hernández, Adrián J., Solís, Camila J., Ulloa, Pilar E.   +7 more
core   +4 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells [PDF]

, 2023
Yifei Chen, Miaojuan Zhu, Jiahao Hu, Shaojun He, Shuhua Li, Bing Liu, Jiong Yang   +6 more
openalex   +1 more source

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Retracted: Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux

Mediators of Inflammation, 2022
Mediators of Inflammation
doaj   +1 more source

Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis

Fluids and Barriers of the CNS
Multiple sclerosis (MS) is a chronic inflammatory disease that has been associated with dysfunction of the protective barriers in the central nervous system (CNS), allowing harmful immune cells to enter.
Junhua Xie, Marlies Burgelman, Pieter Dujardin, Jonas Castelein, Griet Van Imschoot, Elien Van Wonterghem, Hannah Lernout, Sjoerd T. T. Schetters, Charysse Vandendriessche, Lien Van Hoecke, Roosmarijn E. Vandenbroucke   +10 more
doaj   +1 more source