Results 221 to 230 of about 4,758,008 (341)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Single-dose DSS-induced inflammation enhances colorectal tumorigenesis in APC and KRAS mutant mice. [PDF]

Sci Rep
Ishibashi K, Urabe Y, Uda T, Sako Y, Gurita T, Masuda S, Hatsushika Y, Nakamura T, Konishi H, Tsuboi A, Tanaka H, Yamashita K, Kishida Y, Hiyama Y, Takigawa H, Kuwai T, Niitsu H, Hinoi T, Oka S.   +18 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Polymorphonuclear Myeloid-Derived Suppressor Cells Promote Inflammation Progression of Rheumatoid Arthritis by Inducing Age-Associated B Cell Proliferation and Differentiation via the BAFF-Mediated SYK-ERK1/2 Pathway [PDF]

Huiming Hong, Fanzhang Yin, Yanan Wang, Yongqi Wang, Jingxue Zhang, Xiaojun Tang, Huayong Zhang, Lingyun Sun   +7 more
openalex   +1 more source

Hyperferritinemia and inflammation [PDF]

, 2017
Kate F. Kernan, Joseph A. Carcillo
openalex   +1 more source

Early C-reactive protein reduction predicts survival in real-world extensive-stage small cell lung cancer treated with first-line adebrelimab-based immunotherapy. [PDF]

Front Oncol
Wang J, Zhang X, Gao Q, Chen J.
europepmc   +1 more source

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice

Diabetes, 2008
Patrice D Cani, R. Bibiloni, C. Knauf, A. Waget, A. Neyrinck, N. Delzenne, R. Burcelin   +6 more
semanticscholar   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Correction: Lin et al. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. J. Clin. Med. 2020, 9, 226 [PDF]

Chih‐Chung Lin, Wei‐Ning Lin, Rou‐Ling Cho, Chien-Chung Yang, Yi-Cheng Yeh, Li‐Der Hsiao, Hui‐Ching Tseng, Chuen‐Mao Yang   +7 more
openalex   +1 more source

Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials [PDF]

, 2016
Li‐Tzu Wang, Chiao-Hsuan Ting, Ming‐Shyen Yen, Ko‐Jiunn Liu, Huey‐Kang Sytwu, Kenneth K. Wu, B. Linju Yen   +6 more
openalex   +1 more source