Results 221 to 230 of about 2,403,937 (295)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Mucosal DNA methylation reveals immune-related methylation profile and correlates with crohn's disease status. [PDF]

Sci Rep
Zhang T, Lin Q, Xu WY, He Q, Gong C, Wang L, Wang Z, Zhong J.   +7 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Understanding obesity-cancer crosstalk to inform the immunomodulatory roles of anti-obesity nanotherapeutics. [PDF]

Mater Today Bio
Zhou F, Li X, Jiang J, Zhang L.
europepmc   +1 more source

MicroRNA‐429 Inhibits Microglial Inflammation by Targeting IKKβ Through the NF‐κB Pathway [PDF]

Zhongling Ke, Yanhui Chen, Xiaoxia Lin, Jilong Jiang   +3 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Failure of γδ T Cell Recovery in the Gut With Effective Anti-HIV Therapy

Journal of Immunology Research
Priscila O. Barros, Stephanie C. Burke Schinkel, Ameeta Lubina Nayak, Brittany Haas, Tamara K. Berthoud, Michaeline McGuinty, D. William Cameron, Jonathan B. Angel   +7 more
doaj   +1 more source

Association of Systemic Markers of Inflammation with Signs and Symptoms of Dry Eye Disease and Sjogren’s Syndrome in the Dry Eye Assessment and Management (DREAM©) Study

Marium H. Hashemi, Julian L. Ambrus, Abhay A. Shukla, Di Zhu, Gui‐Shuang Ying, Penny A. Asbell, Dry Eye Assessment and Management (DREAM) Study Research Group   +6 more
openalex   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source