THE ANEMIA OF INFECTION. III. THE UPTAKE OF RADIO-ACTIVE IRON IN IRON-DEFICIENT AND IN PYRIDOXINE-DEFICIENT PIGS BEFORE AND AFTER ACUTE INFLAMMATION 1 [PDF]
M. M. Wintrobe+5 more
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ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee+9 more
wiley +1 more source
EXPERIMENTAL STUDIES ON THE CHRONIC INFLAMMATION AND THE MUCOCELE OF THE SINUS
Y. TOMODA
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In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella+18 more
wiley +1 more source
Pathological Researches of Inflammation of the Veins of the Uterus, with Additional Observations on Phlegmasia Dolens [PDF]
Robert Lee
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This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima+6 more
wiley +1 more source
Art. XXI.—Boylston Prize Dissertation, for the years 1838 and 1839, on Scrofula, Rheumatism, and Erysipelatous Inflammation. [PDF]
Edward Warren
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Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides+13 more
wiley +1 more source
Nivolumab-Induced Refractory Hemorrhagic Gastritis and Duodenitis Requiring Multimodal Biologic Therapy. [PDF]
Shibu R+4 more
europepmc +1 more source