Results 71 to 80 of about 3,799,228 (259)

The nuclear factor NF-kappaB pathway in inflammation.

Cold Spring Harbor Perspectives in Biology, 2009
The nuclear factor NF-kappaB pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappaB in the expression of proinflammatory genes including cytokines, chemokines, and adhesion molecules.
T. Lawrence
semanticscholar   +1 more source

Hypoxia and Inflammation [PDF]

New England Journal of Medicine, 2011
To the Editor: In their review article on hypoxia and inflammation, Eltzschig and Carmeliet (Feb. 17 issue)1 were thorough in promoting the role of hypoxia-inducible transcription factor (HIF) and related mechanisms to regain homeostasis in hypoxic tissue environments. Although very exacting in its discussion, the review unfortunately failed to include
Jo-Dee L. Lattimore, Kim H. Chan, Ian Wilcox   +2 more
openaire   +5 more sources

Systemic inflammation and residual viraemia in HIV-positive adults on protease inhibitor monotherapy: a cross-sectional study. [PDF]

, 2015
Increased levels of markers of systemic inflammation have been associated with serious non-AIDS events even in patients on fully suppressive antiretroviral therapy.
Arenas-Pinto, A, Gilson, R, Maini, M, McKendry, A, Milinkovic, A, Peppa, D   +5 more
core   +1 more source

IL-6 in inflammation, immunity, and disease.

Cold Spring Harbor Perspectives in Biology, 2014
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions.
Toshio Tanaka, M. Narazaki, T. Kishimoto
semanticscholar   +1 more source

Midkine in Inflammation

The Scientific World JOURNAL, 2011
The 13 kDa heparin-binding growth factor midkine (MK) was originally identified as a molecule involved in the orchestration of embryonic development. Recent studies provided evidence for a new role of MK in acute and chronic inflammatory processes. Accordingly, several inflammatory diseases including nephritis, arthritis, atherosclerosis, colitis, and ...
Takashi Muramatsu, Barbara Walzog, Ludwig T. Weckbach   +2 more
openaire   +4 more sources

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]

, 2018
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro, García Domínguez, Irene, García Revilla, Juan, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Santiago Pavón, Martiniano, Venero Recio, José Luis, Veselá, Karolina   +7 more
core   +3 more sources

Sex-specific roles of cellular inflammation and cardiometabolism in obesity-associated depressive symptomatology. [PDF]

, 2019
BackgroundObesity and depression are complex conditions with stronger comorbid relationships among women than men. Inflammation and cardiometabolic dysfunction are likely mechanistic candidates for increased depression risk, and their prevalence differs ...
Cabrera, Yesenia, Dimitrov, Stoyan, Guay-Ross, Nicholas, Hong, Suzi, Kohn, Jordan N, Pruitt, Christopher, Shaikh, Farah D   +6 more
core   +1 more source

Resolving an inflammatory concept: the importance of inflammation and resolution in tendinopathy [PDF]

, 2014
Injuries to the superficial digital flexor tendon (SDFT) are an important cause of morbidity and mortality in equine athletes, but the healing response is poorly understood.
Abayasekara, Alfredson, Almekinders, Almekinders, Archambault, Astrom, Attur, Attur, Avella, Birch, Christensen, Cohen, Crevier-Denoix, Dakin, Dakin, Dakin, Dowling, Dudhia, Dunn, Evans, Ferry, Funk, Gilroy, Gilroy, Gilroy, Graham, Hosaka, Irvine, Jackson, Jakobsson, Jarvinen, Jayesh Dudhia, Jozsa, Kannus, Ker, Khan, Kojima, Kujala, Lands, Langberg, Leask, Levy, Li, Lin, Longo, Lui, Magra, Marsolais, Millar, Molloy, Morris, Navarro-Xavier, Petrucci, Rajakariar, Riley, Roger K.W. Smith, Ruwanpura, Saito, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Serhan, Shrier, Smith, Smith, Stables, Stephanie G. Dakin, Strocchi, Sullo, Sun, Thampatty, Thorpe, Tilley, Tsuzaki, van der Pouw Kraan, Videla, Virchenko, Wang, Webbon, Williams, Wilson, Wynn, Yang, Yang, Ye, Zhang   +91 more
core   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +3 more sources

Reactive oxygen species in inflammation and tissue injury.

Antioxidants and Redox Signaling, 2014
Reactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. An enhanced ROS generation by polymorphonuclear neutrophils (PMNs) at the site of inflammation causes endothelial ...
M. Mittal, M. Siddiqui, Khiem Tran, S. Reddy, A. Malik   +4 more
semanticscholar   +1 more source