Results 71 to 80 of about 2,403,937 (295)

Interferon α2 and interferon γ induce the degranulation independent production of VEGF‐A and IL‐1 receptor antagonist and other mediators from human mast cells

Immunity, Inflammation and Disease, 2018
Background Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and ...
Sharon A. Oldford, Suzanne P. Salsman, Liliana Portales‐Cervantes, Raidan Alyazidi, Robert Anderson, Ian D Haidl, Jean S. Marshall   +6 more
doaj   +1 more source

Biomarkers of Coagulation and Inflammation in COVID-19–Associated Ischemic Stroke

, 2021
Charles Esenwa, Natalie Cheng, Jorge Luna, Joshua Z. Willey, Amelia K. Boehme, Kathryn F. Kirchoff-Torres, Daniel Labovitz, Ava L. Liberman, Peter C. Mabie, Khadean Moncrieffe, Ainie Soetanto, Andrea Lendaris, Johanna Seiden, Inessa Goldman, David Altschul, Ryan Holland, Joshua Benton, Joseph Dardick, Jenelys Fernandez-Torres, David Flomenbaum, Jenny Lu, Avinash Malaviya, Nikunj Patel, Aureliana Toma, Aaron Lord, Koto Ishida, Jose Torres, Thomas E. Snyder, Jennifer Frontera, Shadi Yaghi   +29 more
openalex   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Effects of carvedilol vs bisoprolol on inflammation and oxidative stress in patients with chronic heart failure [PDF]

, 2019
Shigeru Toyoda, Akiko Haruyama, Shu Inami, Takuo Arikawa, Fumiya Saito, Ryo Watanabe, Masashi Sakuma, Shichiro Abe, Toshiaki Nakajima, Atsushi Tanaka, Koichi Node, Teruo Inoue   +11 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Retracted: Activation of CD137 Signaling Enhances Vascular Calcification through c-Jun N-Terminal Kinase-Dependent Disruption of Autophagic Flux

Mediators of Inflammation, 2022
Mediators of Inflammation
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Retracted: Neuropilin-1highCD4+CD25+ Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis

Mediators of Inflammation, 2020
Mediators of Inflammation
doaj   +1 more source

Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis

Fluids and Barriers of the CNS
Multiple sclerosis (MS) is a chronic inflammatory disease that has been associated with dysfunction of the protective barriers in the central nervous system (CNS), allowing harmful immune cells to enter.
Junhua Xie, Marlies Burgelman, Pieter Dujardin, Jonas Castelein, Griet Van Imschoot, Elien Van Wonterghem, Hannah Lernout, Sjoerd T. T. Schetters, Charysse Vandendriessche, Lien Van Hoecke, Roosmarijn E. Vandenbroucke   +10 more
doaj   +1 more source