Results 111 to 120 of about 3,890,295 (331)

Retracted: The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages

Mediators of Inflammation, 2020
Mediators of Inflammation
doaj   +1 more source

Characteristics of inflammatory mediators in dental pulp inflammation and the potential for their control

Frontiers in Dental Medicine
Dental pulp is a mesenchymal connective tissue located inside the rigid encasement of the dentin. When bacteria or bacterial products invade the dental pulp, inflammation known as pulpitis is induced in this tissue.
Nobuyuki Kawashima, Takashi Okiji
doaj   +1 more source

CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood–brain barrier breakdown [PDF]

, 1998
Daniel C. Anthony, Robert Dempster, Sara Fearn, John M. Clements, Graham Wells, V. Hugh Perry, Katharine Walker   +6 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The role of polymorphonuclear leukocytes and oxygen‐derived free radicals in experimental acute pancreatitis: mediators of local destruction and activators of inflammation [PDF]

, 1999
Bertram Poch, Frank Gansauge, Bettina Rau, Uwe A. Wittel, Susanne Gansauge, Andreas K. Nüssler, Michael Schoenberg, H. G. Beger   +7 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

In regards to lipoxins as lipid mediators for the resolution of inflammation using the example of asthma

Acta Biomedica Scientifica
Asthma is the most important medical and social problem of our time due to its widespread prevalence, chronic course and heterogeneity, which determines the complexity of  treating this disease.
O. Yu. Kytikova, T. P. Novgorodtseva, I. S. Kovalenko   +2 more
doaj   +1 more source

Helicobacter pylori-Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-γ, Gene-Deficient Mice [PDF]

, 2000
Lesley E. Smythies, Ken B. Waites, J. Russell Lindsey, Paul Harris, P Ghiara, Phillip D. Smith   +5 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Protease-Activated Receptor 1 Mediates Thrombin-Dependent, Cell-Mediated Renal Inflammation in Crescentic Glomerulonephritis [PDF]

, 2000
Malcolm A. Cunningham, Éric Rondeau, Xin Chen, Shaun R. Coughlin, Stephen R. Holdsworth, Peter G. Tipping   +5 more
openalex   +1 more source