Results 211 to 220 of about 635,488 (322)

Supplementary Figure S2 from Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer [PDF]

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi, Vanessa T. Garrido, Zhiqun Zhou, Andrew Adams, Haleh Amirian, Edmond W. Box, Xiaodian Sun, Yuguang Ban, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant   +14 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Inflammation impairs post-hospital discharge growth among children hospitalised with acute illness in sub-Saharan Africa and south Asia. [PDF]

Nat Commun
Njunge JM, Mudibo EO, Bogaert J, Orindi B, Sande CJ, Bourdon C, Tigoi C, Ngari MM, Ngao N, Omer E, Gumbi W, Musyimi R, Timbwa M, Mwaringa S, Gwela A, Thitiri J, Mupere E, Lancioni CL, Gonzales GB, Singa BO, Mbale E, Voskuijl WP, Denno DM, Diallo AH, Bamouni RM, Chisti MJ, Shahid ASMSB, Ahmed T, Saleem AF, Ali SA, Uhlig HH, Tickell KD, Bandsma RHJ, Walson JL, Berkley JA.   +34 more
europepmc   +1 more source

MP070A POLYMER CONJUGATE NANOMEDICINE INHIBITS LPS-INDUCED MAPK ACTIVATION AND REDUCES ENDOTOXEMIA-MEDIATED KIDNEY INFLAMMATION [PDF]

, 2017
Cristian González‐Guerrero, Marı́a J. Vicent, Alberto Ortíz, Adrián M. Ramos   +3 more
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication. [PDF]

Mol Biomed
Li C, Wang Z, Yang Y, Jiang Q, Jiang Y, Xiao J, Shen L, Wu W, Li C.   +8 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Editorial: Hunting for inflammation mediators: identifying novel biomarkers for autoimmune and autoinflammatory diseases

Frontiers in Immunology
Li Zeng, Yu Fang, Shintaro Horie, Jian Liu   +3 more
doaj   +1 more source

The impact of gut-liver-derived mediators on the organ crosstalk with brain, heart, and kidney: A systematic review. [PDF]

Mol Metab
Bhargava S, Rao Z, Vanholder R, Tacke F, Noels H, Jankowski V, Hermann J, Jankowski J.   +7 more
europepmc   +1 more source

Proteinases [PDF]

, 1993
Fritz, Hans, Jochum, Marianne, Machleidt, W., Neuhof, H., Redl, H., Schlag, Günther   +5 more
core   +1 more source