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Cytokine Mediators of Immunity and Inflammation
Archives of Surgery, 1993The remarkable advances in molecular and cell biology occurring over the past four decades have served the cause of surgical science well. Our understanding of basic disease mechanisms and insights into potential new therapeutic strategies have occurred at a staggering pace.
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Neurokinin mediation of edema and inflammation
Neuropeptides, 2000The aim of this article is to furnish a brief review of the role played by neurokinins in the inflammatory process. Further attention is given to the mechanisms, as well as to the receptor subtypes involved in neurokinin-mediated inflammation, in an attempt to clarify the participation of neurokinins in different models of acute and chronic ...
M M, Campos, J B, Calixto
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Cationic antigens as mediators of inflammation
APMIS, 1991Electrical charge is an important determinant of antigen deposition in tissue. Cationic antigens can bind to anionic sites found in many organs. The major focus of interest has been the renal glomerulus and the articular joint. Experimental models of immune complex glomerulonephritis and allergic arthritis were established with chemically cationized ...
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PGI2: A potential mediator of inflammation
Prostaglandins, 1978PGI2, but not its metabolite 6oxoPGF1alpha, is equivalent in potency to PGE1 as a potentiator of carrageenan, histamine and bradykinin-induced rat paw oedemas. PGI2 must, therefore, be considered as a potential mediator of inflammatory processes.
A W, Ford-Hutchinson +3 more
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Update on Histamine as a Mediator of Inflammation
Allergy and Asthma Proceedings, 2000Histamine is an important mediator and regulator of inflammation. Histamine acts via H1, H2, and H3 receptors that are functionally coupled to G-proteins and histamine release is regulated by cytokines that act as histamine release factors. Histamine suppresses the immune response and deviates the immune response toward the Th2 pathway.
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1974
1. The Mediators of Inflammation.- 2. Mechanisms Common to Several Mediator Systems.- 2.1. Cellular Release.- 2.2. Fluid-Phase Activation.- 2.3. Bypass Mechanisms.- 2.4. Extracellular Control Loops.- 2.5. Intracellular Controls.- 3. Centrality of Phagocytes.- 4. References.- 1 Mechanisms of Mediator Release from Inflammatory cells.- 1. Introduction.- 2.
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1. The Mediators of Inflammation.- 2. Mechanisms Common to Several Mediator Systems.- 2.1. Cellular Release.- 2.2. Fluid-Phase Activation.- 2.3. Bypass Mechanisms.- 2.4. Extracellular Control Loops.- 2.5. Intracellular Controls.- 3. Centrality of Phagocytes.- 4. References.- 1 Mechanisms of Mediator Release from Inflammatory cells.- 1. Introduction.- 2.
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Mediators of inflammation and the inflammatory process
Journal of Allergy and Clinical Immunology, 1999A complex interplay of inflammatory cells and chemical mediators is responsible for allergic inflammation. It is now understood that the allergic reaction consists of an early-phase response involving mast cell degranulation with the release of histamine and a late-phase response characterized by the migration of inflammatory cells.
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Cytokine mediators of renal inflammation
Current Opinion in Nephrology and Hypertension, 1994This review focuses on the role of two cytokines, platelet-derived growth factor and transforming growth factor-beta, in glomerular injury. The most recent in vitro and in vivo evidence for the role of platelet-derived growth factor and transforming growth factor-beta in glomerular hypercellularity and matrix expansion is summarized.
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Bacterial Mediated Gastrointestinal Inflammation
2013Mouse models have proven to be a key approach in our understanding of the etiology and physiology underlying bacterial mediated gastrointestinal inflammation. Generally, these models are based on the inoculation of genetically susceptible mice with either commensal or pathogenic bacteria to elicit an inflammatory response.
Joshua, Uronis, Xiaolun, Sun
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