Results 31 to 40 of about 569,903 (346)

Noisy NFkB oscillations stabilize and sensitize cytokine signaling in space [PDF]

, 2012
NF-kB is a major transcription factor mediating inflammatory response. In response to pro-inflammatory stimulus, it exhibits characteristic response -- a pulse followed by noisy oscillations in concentrations of considerably smaller amplitude. NF-kB is an important mediator of cellular communication, as it is both activated by and upregulates ...
arxiv   +1 more source

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases [PDF]

, 2014
Inflammation is associated with the development of diseases characterized by altered nutrient metabolism. Although an acute inflammatory response is host-protective and normally self-limited, chronic low-grade inflammation associated with metabolic ...
Clària, Joan, Serhan, Charles N., Spite, Matthew   +2 more
core   +1 more source

Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modeling [PDF]

arXiv, 2023
Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours. Several studies hypothesize that the latter better represents the prolonged and pronounced inflammation observed in conditions like sepsis.
arxiv  

Unraveling the Link between Periodontitis and Inflammatory Bowel Disease: Challenges and Outlook [PDF]

arXiv, 2023
Periodontitis and Inflammatory Bowel Disease (IBD) are chronic inflammatory conditions, characterized by microbial dysbiosis and hyper-immunoinflammatory responses. Growing evidence suggest an interconnection between periodontitis and IBD, implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle.
arxiv  

Targeting neuroinflammation in Alzheimer’s disease [PDF]

, 2016
Almost 47 million people suffer from dementia worldwide, with an estimated new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately 60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one
Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca   +3 more
core   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

Resolution of Inflammation in Neurodegenerative Diseases: The Role of Resolvins

Mediators of Inflammation, 2020
Acute inflammation has been described as a reactive dynamic process, promoted by the secretion of proinflammatory mediators, including lipid molecules like leukotrienes and prostaglandins, and counterbalanced by proresolving mediators including omega-3 ...
Sajad Chamani, Vanessa Bianconi, Aida Tasbandi, Matteo Pirro, George E. Barreto, Tannaz Jamialahmadi, Amirhossein Sahebkar   +6 more
doaj   +1 more source

Objective cough frequency, airway inflammation, and disease control in asthma [PDF]

, 2016
Background Cough is recognized as an important troublesome symptom in the diagnosis and monitoring of asthma. Asthma control is thought to be determined by the degree of airway inflammation and hyperresponsiveness but how these factors relate to cough
Ashley Woodcock, Baharudin Ibrahim, Cazzoletti, Cox, Crapo, de Marco, Decalmer, Deykin, Green, Haldar, Imran Satia, Iona Donnelly, Jaclyn A. Smith, Jayaram, Juniper, Kelsall, Langley, Langley, Langley, Lisa Jolly, Lucy Yates, Manfreda, Marsden, Miller, Mincheva, Morjaria, Neil C. Thomson, Osman, Paul A. Marsden, Pavord, Prieto, Quaedvlieg, Shaw, Smith, Sont, Stephen J. Fowler, Sumino, Sumner, Szefler, Thomson, Volbeda, Widdicombe   +41 more
core   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Resolution of inflammation: Therapeutic potential of pro-resolving lipids in Type 2 diabetes mellitus and associated renal complications

Frontiers in Immunology, 2012
The role of inflammation in the pathogenesis of type 2 diabetes mellitus (T2DM) and its associated complications is increasingly recognized. The resolution of inflammation is actively regulated by endogenously produced lipid mediators such as lipoxins ...
Emma eBorgeson, Catherine eGodson
doaj   +1 more source