Results 51 to 60 of about 569,903 (346)

TL1A: A mediator of gut inflammation [PDF]

Proceedings of the National Academy of Sciences, 2006
In this issue of PNAS, a team of investigators led by Giorgos Bamias and Fabio Cominelli at the University of Virginia Health Science Center (Charlottesville, VA) in collaboration with the laboratory of Giorgos Kollias at the Alexander Fleming Biomedical Sciences Research Center (Athens, Greece) report on the role of TL1A (a TNF superfamily member) in ...
Howard A. Young, Michael G. Tovey
openaire   +3 more sources

Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs [PDF]

, 2018
Remote damage is a secondary phenomenon that usually occurs after a primary brain damage in regions that are distant, yet functionally connected, and that is critical for determining the outcomes of several CNS pathologies, including traumatic brain and ...
Besharat, Zein Mersini, Bisicchia, Elisa, Catanzaro, Giuseppina, Chiacchiarini, Martina, Chiurchiù, Valerio, Ferretti, Elisabetta, Leuti, Alessandro, Molinari, Marco, Sasso, Valeria, Viscomi, Maria Teresa   +9 more
core   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

The Involvement of Lipid Mediators in the Mechanisms of Exercise-Induced Muscle Damage

Physiologia, 2023
Lipid mediators are a class of signaling molecules that play important roles in various physiological processes, including inflammation, blood pressure regulation, and energy metabolism.
Athanasios G. Gakis, Tzortzis Nomikos, Anastassios Philippou, Smaragdi Antonopoulou   +3 more
doaj   +1 more source

Gaseous mediators in resolution of inflammation

Seminars in Immunology, 2015
There are numerous gaseous substances that can act as signaling molecules, but the best characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has been shown to play important roles in many physiological and pathophysiological processes.
Wallace, John L, IANARO, ANGELA, Flannigan, Kyle L., CIRINO, GIUSEPPE   +3 more
openaire   +5 more sources

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Association of an expanded inflammatory mediators response with clinical and laboratory data in the postoperative period of pulmonary resection: a prospective clinical study

Revista do Colégio Brasileiro de Cirurgiões, 2021
Introduction: patients undergoing pulmonary resection may experience local or remote complications in the postoperative period due to the inflammatory response, which increases the length of hospital stay and costs. This study objective was to establish
LUCIARA IRENE DE NADAI DIAS, VALESKA DALANEZI PAULINO LEITE, JÚLIA MENDES BRANDÃO, ANDREA PELICIA ROSO, ELIANA CRISTINA MARTINS MIRANDA, EDSON ANTUNES, RICARDO KALAF MUSSI   +6 more
doaj   +2 more sources

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Pain pathogenesis in rheumatoid arthritis -- what have we learned from animal models [PDF]

PAIN 2018 Sep; 159 Suppl:S98-S109, 2019
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as pain, will disappear. However, pain is the most common complaint of RA patients, is often still present
arxiv   +1 more source