Results 101 to 110 of about 4,616,582 (290)

Effect of β-Caryophyllene on PPAR-γ, NF-κB, and CNR2: Implications for Gut–Brain Axis Communication in a Murine Model of Diet-Induced Obesity

Metabolites
Background /Objectives: The rising prevalence of metabolic disorders, such as obesity, is linked to increased consumption of high-calorie foods and sedentary lifestyles.
Cristina Pech-Jiménez, Lucrecia Carrera-Quintanar, Juan Manuel Viveros-Paredes, Yolanda Fabiola Marquez-Sandoval, Luis Felipe Jave-Suárez, Adelaida Sara Minia Zepeda-Morales, Gilberto Velázquez-Juárez, Rocio Ivette López-Roa   +7 more
doaj   +1 more source

Dual inhibitory activities of Adhatoda Vasica against cyclooxygenase and lipoxygenase

International Journal of Endorsing Health Science Research, 2013
Adhatoda vasica (L.) Nees is a well-known plant drug in Ayurvedic and Unani medicine. It has been used for the treatment of various diseases, particularly for the treatment of inflammatory and cardiovascular diseases.
Sagheer Ahmed, Saima Gul, Humera Gul, Muhammad Hanif Bangash   +3 more
doaj   +1 more source

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease. [PDF]

, 2018
BACKGROUND: Patients with primary sclerosing cholangitis associated with inflammatory bowel disease (PSC-IBD) have a very high risk of developing colorectal neoplasia.
Bao, X, Brito, H, Moura-Santos, P, Oliveira, A, et al., Palmela, C, Ruiqi, H, Silva, J, Torres, J   +7 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Short-term Outcomes and Associated Factors of Postoperative Complications following Laparoscopic Ileocecal Resection in Complex Crohn's Disease

Journal of the Anus, Rectum and Colon
Objectives: Minimally invasive surgery (MIS) is widely used for Crohn's disease (CD), but its feasibility in complex CD is still debated. This study aimed to evaluate short-term outcomes and identify factors associated with major complications following ...
Eiichi Nakao, Kenji Tatsumi, Nao Obara, Koki Goto, Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei   +6 more
doaj  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Effects of Dietary Supplementation with 25-Hydroxyvitamin D3 on the Antioxidant Capacity and Inflammatory Responses of Pelteobagrus fulvidraco

Biology
Based on the limited hepatic hydroxylation efficiency of dietary VD3 in teleosts and the superior bioavailability of its metabolite, 25(OH)D3, this study investigated the regulatory mechanisms of dietary 25(OH)D3 supplementation in yellow catfish—an ...
Yi Liu, Jiang Xie, Qingchao Shi, Quan Gong, Chuanjie Qin   +4 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Exploring the interplay of prolactin and bromocriptine on serum markers in granulomatous lobular mastitis

Frontiers in Immunology
ObjectiveIn this study, we retrospectively analyzed the relationship between PRL level and serum inflammatory and immune markers in patients with granulomatous lobular mastitis (GLM) and analyzed the effect of bromocriptine treatment on serum ...
Binheng Liu, Wenchao Qu, Yi Feng, Xueqing Wu, Jiamei Feng, Qingqian Gao, Shijun Shao, Jiaye Sun, Hua Wan, Weiping Chen   +9 more
doaj   +1 more source

Honey anti-inflammatory factor identified [PDF]

, 2012
Four different brands of honey wound dressings are now on sale internationally as registered medical devices, all made from manuka honey because of its well-established reputation as an antibacterial agent.
Molan, Peter C.
core   +1 more source