Results 81 to 90 of about 4,054,897 (306)

Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation [PDF]

, 2010
Introduction: Hypothermia improves survival and neurological recovery after cardiac arrest. Pro-inflammatory cytokines have been implicated in focal cerebral ischemia/reperfusion in-jury.
Meybohm, Patrick, Zitta, Karina, Grünewald, Matthias Lars, Albrecht, Martin, Zacharowski, Kai, Lucius, Ralph, Hensler, Johannes, Bein, Berthold, Fösel, Nikola, Matthias Gruenewald, Martin Albrecht, Johannes Hensler, Karina Zitta, Kai D Zacharowski, Patrick Meybohm, Nikola Fösel, Berthold Bein, Ralph Lucius   +17 more
core   +1 more source

Utility of Hybrid Endoscopy Combining Small‐Bowel Capsule Endoscopy and Conventional Ileocolonoscopy in Crohn's Disease

DEN Open
Objectives To evaluate the safety and utility of hybrid endoscopy for whole‐bowel assessment in Crohn's disease (CD) and its role in treatment decision‐making.
Takahiro Ito, Kohei Matsunaga, Yuya Ohno, Muchir Shi, Atsuo Maemoto   +4 more
doaj   +1 more source

Retrospective analysis of inflammatory biomarkers and prognosis in non-small cell lung cancer without adenocarcinoma in situ

Frontiers in Genetics
BackgroundInflammatory biomarkers have shown prognostic value in Non-Small Cell Lung Cancer (NSCLC), but the inclusion of Adenocarcinoma In Situ (AIS) cases in previous studies may introduce bias.
Qing Zhao, Songping Cui, Bin Hu, Shuo Chen   +3 more
doaj   +1 more source

Exposure to gold nanoparticles produces cardiac tissue damage that depends on the size and duration of exposure

Lipids in Health and Disease, 2011
Background Current research focuses on cancer therapy, diagnostics and imaging, although many challenges still need to be solved. However, for the application of gold nanoparticles (GNPs) in therapy and diagnostics it is necessary to know the ...
Abdelhalim Mohamed Anwar K
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Oral Administration of Propolis and Lysozyme Combination Improves Feline Oral Health and Modulates Systemic Inflammatory and Oxidative Responses

Antioxidants
Oral diseases are highly prevalent among domestic cats, with microbiota dysbiosis as a primary etiological factor. However, effective microbiota-targeted interventions remain limited.
Longjiao Wang, Qianqian Chen, Weiwei Wang, Hao Dong, Xiaohan Chang, Lishui Chen, Ran Wang, Yaoxing Chen, Pengjie Wang, Shuxing Chen, Wei Xiong, Yixuan Li   +11 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

CARMIL2 Deficiency Presenting as Very Early Onset Inflammatory Bowel Disease [PDF]

, 2019
Background: Children with very early onset inflammatory bowel diseases (VEO-IBD) often have a refractory and severe disease course. A significant number of described VEO-IBD-causing monogenic disorders can be attributed to defects in immune-related genes.
Conca, Raffaele, Jeske, Tim, Hollizeck, S, Mukhina, Anna, Meino Rohlfs, Conca, R, Yulia Rodina, Shcherbina, Anna, Muise, Aleixo M, Illig, D, Shcherbina, A, Klein, Christoph, Rodina, Y, Mukesh M Desai, Wall, Sarah, Kotlarz, D, Muise, AM, Gothe, Florian, Tim Jeske, Koletzko, Sibylle, David Illig, Snapper, SB, Rodina, Yulia, Daniel Kotlarz, Sebastian Hollizeck, Eberhard Lurz, Karacabey, N, Hauck, F, Raffaele Conca, Taur, Prasad D, Arslan, DURAN, Rohlfs, Meino, Schober, T, Mukhina, A, Koletzko, S, Neslihan Karacabey, Marquardt, Benjamin, Scott B Snapper, Hauck, Fabian, Tilmann Schober, Magg, Thomas, Anna Mukhina, Desai, Mukesh M, Vanessa Mitsialis, Wall, S, Christoph Klein, Rohlfs, M, Benjamin Marquardt, Florian Gothe, Hollizeck, Sebastian, Sarah Wall, Schober, Tilmann, Ekrem Unal, Mitsialis, Vanessa, Anna Shcherbina, Prasad D Taur, Thomas Magg, Lurz, Eberhard, Duran Arslan, Gothe, F, Klein, C, Kotlarz, Daniel, Magg, T, Aleixo M Muise, Marquardt, B, Jeske, T, Taur, PD, Karacabey, Neslihan, Illig, David, Unal, EKREM, Fabian Hauck, Snapper, Scott B, Desai, MM, Mitsialis, V, Lurz, E, Sibylle Koletzko, Klein Christoph, Shcherbina Anna, Desai Mukesh M, ARSLAN DURAN, Rodina Yulia, Gothe Florian, Hauck Fabian, Wall Sarah, Jeske Tim, Conca Raffaele, Lurz Eberhard, KARACABEY NESLİHAN, Mukhina Anna, Mitsialis Vanessa, Snapper Scott B, Koletzko Sibylle, Rohlfs Meino, Marquardt Benjamin, Muise Aleixo M, Illig David, Schober Tilmann, Taur Prasad D, ÜNAL EKREM, Hollizeck Sebastian, Kotlarz Daniel, Magg Thomas   +101 more
core   +1 more source

Valproic Acid Attenuates Traumatic Brain Injury-Induced Inflammation in Vivo: Involvement of Autophagy and the Nrf2/ARE Signaling Pathway

Frontiers in Molecular Neuroscience, 2018
Microglial activation and the inflammatory response in the central nervous system (CNS) play important roles in secondary damage after traumatic brain injury (TBI).
Xiangrong Chen, Xiangrong Chen, Handong Wang, Mengliang Zhou, Xiang Li, Zhongning Fang, Hongzhi Gao, Yasong Li, Weipeng Hu   +8 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source