Results 71 to 80 of about 4,054,897 (306)

Role of Interleukin-33 in Immunity and Periodontal Inflammation-A Literature Review [PDF]

Journal of Clinical and Diagnostic Research, 2018
The Interleukin-33 (IL-33) is a member of IL-1 family discovered in the year of 2005. The Interleukin-1 (IL-1) family of cytokines is commonly encountered in chronic inflammatory diseases such as rheumatoid arthritis and periodontitis.
Sasi Kumar Karuppanan, Santhosh Sekar, Sakthi Saranya Devi   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes [PDF]

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core  

Inflammatory dentigerous cyst mimicking a periapical cyst

Journal of International Clinical Dental Research Organization, 2016
Odontogenic cysts are the most common form of cystic lesions that affect the maxillofacial region. The low frequency of dentigerous cysts in children has been reported in dental literature.
Priya Gupta, Manveen Kaur Jawanda, Ravi Narula, Jasheena Singh   +3 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Altered immune cell in human severe acute pancreatitis revealed by single-cell RNA sequencing

Frontiers in Immunology
BackgroundSevere acute pancreatitis (SAP) is characterized by inflammation, with inflammatory immune cells playing a pivotal role in disease progression.
Zheyi Wu, Zheyi Wu, Shijie Wang, Zhiheng Wu, Junjie Tao, Lei Li, Chuanming Zheng, Zhipeng Xu, Zhaohui Du, Chengpu Zhao, Pengzhen Liang, Aman Xu, Zhenjie Wang, Zhenjie Wang   +13 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Takayasu arteritis beyond the young: What to consider?

Annals of Vascular Surgery - Brief Reports and Innovations
Background: Takayasu arteritis (TA), also known as the pulseless disease, is a rare systemic inflammatory condition that damages medium and larger arteries.
Suci Indriani, Averina Geffanie Suwana, Suko Adiarto, Taofan, Ruth Grace Aurora, Iwan Dakota   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source