Results 101 to 110 of about 4,677,756 (310)

Effect of β-Caryophyllene on PPAR-γ, NF-κB, and CNR2: Implications for Gut–Brain Axis Communication in a Murine Model of Diet-Induced Obesity

Metabolites
Background /Objectives: The rising prevalence of metabolic disorders, such as obesity, is linked to increased consumption of high-calorie foods and sedentary lifestyles.
Cristina Pech-Jiménez, Lucrecia Carrera-Quintanar, Juan Manuel Viveros-Paredes, Yolanda Fabiola Marquez-Sandoval, Luis Felipe Jave-Suárez, Adelaida Sara Minia Zepeda-Morales, Gilberto Velázquez-Juárez, Rocio Ivette López-Roa   +7 more
doaj   +1 more source

Dual inhibitory activities of Adhatoda Vasica against cyclooxygenase and lipoxygenase

International Journal of Endorsing Health Science Research, 2013
Adhatoda vasica (L.) Nees is a well-known plant drug in Ayurvedic and Unani medicine. It has been used for the treatment of various diseases, particularly for the treatment of inflammatory and cardiovascular diseases.
Sagheer Ahmed, Saima Gul, Humera Gul, Muhammad Hanif Bangash   +3 more
doaj   +1 more source

A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds [PDF]

, 2010
Complement factor C5a is one of the most powerful pro-inflammatory agents involved in recruitment of leukocytes, activation of phagocytes and other inflammatory responses.
AJ Wright, Anton Bunschoten, B Postma, B Postma, BO Gerber, Carla J. C. de Haas, CE Stotz, DE Epps van, F Blanco, H Lee, J Cavanagh, JH Ippel, JJ Chen, Johan Kemmink, Johannes H. Ippel, John A. W. Kruijtzer, KE Veldkamp, LM Proctor, Louris Feitsma, M Allegretti, M Farzan, PJ Haas, PN Monk, RF Guo, Rob M. J. Liskamp, TS Haque, ZG Chen   +26 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction [PDF]

, 2015
Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase
Cantatore, S, De Carlo, D, Fineschi, Vittorio, Fiore, C, Neri, M, Riezzo, I, Turillazzi, E   +6 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Effects of Dietary Supplementation with 25-Hydroxyvitamin D3 on the Antioxidant Capacity and Inflammatory Responses of Pelteobagrus fulvidraco

Biology
Based on the limited hepatic hydroxylation efficiency of dietary VD3 in teleosts and the superior bioavailability of its metabolite, 25(OH)D3, this study investigated the regulatory mechanisms of dietary 25(OH)D3 supplementation in yellow catfish—an ...
Yi Liu, Jiang Xie, Qingchao Shi, Quan Gong, Chuanjie Qin   +4 more
doaj   +1 more source

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Short-term Outcomes and Associated Factors of Postoperative Complications following Laparoscopic Ileocecal Resection in Complex Crohn's Disease

Journal of the Anus, Rectum and Colon
Objectives: Minimally invasive surgery (MIS) is widely used for Crohn's disease (CD), but its feasibility in complex CD is still debated. This study aimed to evaluate short-term outcomes and identify factors associated with major complications following ...
Eiichi Nakao, Kenji Tatsumi, Nao Obara, Koki Goto, Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei   +6 more
doaj