Results 101 to 110 of about 4,054,897 (306)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Ethnic variation in inflammatory profile in tuberculosis [PDF]

, 2013
Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro.
Bothamley, GH, Baker Lucy V., Nikolayevskyy, V, Barker, Richard D., Adrian R. Martineau (136644), Heather J Milburn, Drobniewski, Francis A., Nuamah, RA, Martineau, AR, Timms Peter M., Francis A. Drobniewski (349928), Coussens, Anna K., Griffiths, CJ, Vladyslav Nikolayevskyy, Drobniewski, FA, Bhaw-Rosun, L, Rosamond A. Nuamah (430904), Kamrul Islam (430894), Coussens Anna K., Francis A Drobniewski, Milburn, HJ, Davidson Robert N., Nuamah Rosamond A., Alleyna P Claxton, Charles A Mein, Yasmeen Hanifa, Yasmeen Hanifa (430893), Drobniewski Francis A., Elkington, Paul T., Graham H. Bothamley (430896), Claxton Alleyna P., Graham H Bothamley, Elkington Paul T., Peter M. Timms (430895), Anna K. Coussens (430892), Davidson, Robert N., Vladyslav Nikolayevskyy (349919), Bhaw-Rosun Leena, Milburn, Heather, Martineau, Adrian R., Paul T. Elkington (364501), Packe, Geoffrey E., Mein, Charles A., Young, Douglas B., Geoffrey E Packe, Martineau Adrian R., Islam, Kamrul, Packe, GE, Mathina Darmalingam, Anna K Coussens, Robert N Davidson, Mathina Darmalingam (430899), Timms, Peter M., Rosamond A Nuamah, Hanifa, Yasmeen, Elkington, PT, Lucy V. Baker (430901), Nikolayevskyy, Vladyslav, Bothamley, Graham H., Richard D. Barker (430902), Milburn, Heather J., Leena Bhaw-Rosun (430903), Robert J Wilkinson, Baker, Lucy V., Darmalingam, M, Wilkinson, Robert J., Christopher J Griffiths, Bothamley Graham H., Robert J. Wilkinson (130050), Hanifa Yasmeen, Claxton, Alleyna P., Kamrul Islam, Darmalingam Mathina, Barker, RD, Peter M Timms, Wilkinson Robert J., Griffiths Christopher J., Islam Kamrul, Nuamah, Rosamond A., Hanifa, Y, Packe Geoffrey E., Barker Richard D., Claxton, AP, Alleyna P. Claxton (430897), Robert N. Davidson (364270), Coussens, AK, Timms, PM, Paul T Elkington, Christopher J. Griffiths (430905), Leena Bhaw-Rosun, Davidson, RN, Milburn Heather J., Griffiths, Christopher J., Lucy V Baker, Geoffrey E. Packe (430898), Richard D Barker, Darmalingam, Mathina, Nikolayevskyy Vladyslav, Heather J. Milburn (430900), Mein, CA, Charles A. Mein (46734), Baker, LV, Wilkinson, RJ, Adrian R Martineau, Mein Charles A., Bhaw-Rosun, Leena, Islam, K   +106 more
core   +1 more source

Short-term Outcomes and Associated Factors of Postoperative Complications following Laparoscopic Ileocecal Resection in Complex Crohn's Disease

Journal of the Anus, Rectum and Colon
Objectives: Minimally invasive surgery (MIS) is widely used for Crohn's disease (CD), but its feasibility in complex CD is still debated. This study aimed to evaluate short-term outcomes and identify factors associated with major complications following ...
Eiichi Nakao, Kenji Tatsumi, Nao Obara, Koki Goto, Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei   +6 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Inflammatory bowel disease-specific autoantibodies in HLA-B27-associated spondyloarthropathies: Increased prevalence of ASCA and pANCA [PDF]

, 2004
Aims: An association between inflammatory bowel disease (IBD) and spondyloarthropathies (SpA) has repeatedly been reported. The aim of the present study was to investigate whether serologic markers of IBD, e. g.
Folwaczny, Christian, Kellner, H., J. Glas, Marker-Hermann, E., R. Gruber, Brumberger, V., V. Brumberger, Glas, J., Gruber, R., H. Kellner, C. Folwaczny, Török, H.-P., E. Märker-Hermann, C. Strasser, Strasser, C., H.-P. Török   +15 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Selenomethionine alleviates LPS-induced PANoptosis in chicken cecum through the ROS/MAPK pathway, thereby mitigating inflammation and microbial dysbiosis

Poultry Science
Selenomethionine (SeMet), a vital organic selenium compound, plays a pivotal role in maintaining redox homeostasis and is extensively utilized as a dietary supplement.
Dan Chen, Huanyi Liu, Wenying Sun, Shiwen Xu   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source