Results 111 to 120 of about 4,054,897 (306)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

QUALITY OF LIFE: A POTENTIALLY USEFUL MEASURE TO INDICATE SUBCLINICAL FLARES IN CROHN'S DISEASE

, 2012
While quality of life (QoL) is a well-recognised outcome measure of Crohn disease (CD) activity, its influence on other outcome measures, including exacerbation of CD is poorly understood.
R. von Känel, A. M. Schoepfer, Pittet, Valérie, P. Juillerat, V. Pittet, Begré, Stefan, Juillerat, Pascal, null null, Cámara, Rafael J A, von Känel, Roland, R. J. A. Cámara, and the Swiss Inflammatory Bowel Disease Cohort Study Group,, S. Begré, Schoepfer, Alain M, Juillerat, P., von Känel, R., Juillerat P, Cámara, R.J., Begré, S., and the Swiss Inflammatory Bowel Disease Cohort Study Group, Schoepfer AM, Begré S, Pittet, V., Cámara RJ, Camara, Rafael, Schoepfer, A.M., Pittet V, von Känel R   +27 more
core   +1 more source

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease [PDF]

, 2010
Nitrite and nitrate are frequently used surrogate markers of nitric oxide (NO) production. Using rat models of acute and chronic DSS-induced colitis we examined the applicability of these and other NO-related metabolites, in tissues and blood, for the ...
Fumito Saijo, Bryan, Nathan S., Chris Andry, Andry, Chris, D. Neil Granger, Saijo, Fumito, Juan Rodriguez, Ivanovic, Marina, Rodriguez, Juan, Bauer, Selena M., Selena M. Bauer, Feelisch, Martin, Vowinkel, Thorsten, Thorsten Vowinkel, Martin Feelisch, Milsom, Alexandra B., Nathan S. Bryan, Alexandra B. Milsom, Granger, D. Neil, Marina Ivanovic   +19 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Inflammatory-related protein concentrations in the LC and plasma in response to contextual re-exposure.

, 2017
Inflammatory-related protein concentrations in the LC and plasma in response to contextual re-exposure.
Casey M. Moffitt (3797839), Calliandra M. Lombard (3797845), Christopher S. Wood (1990090), Susan K. Wood (3797848), L. Britt Wilson (3797851), Julie E. Finnell (3797842), Akhila R. Padi (3797836)   +6 more
core   +1 more source

COVID‐19‐Associated Cytotoxic Lesions of the Corpus Callosum in Chinese Patients: A Retrospective Study

Brain and Behavior
Background and purpose Cytotoxic lesions of the corpus callosum (CLOCCs) are a rare clinicoradiologic syndrome, exceptionally rare in association with coronavirus disease (COVID‐2019). This study aimed to investigate the neurological features of COVID‐19‐
Chenyi Wan, Menghua Li, Yanyan Yu, Si Luo, Daojun Hong, Meihong Zhou, Yu Zhu   +6 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Inflammatory Bowel Diseases : 2nd Nestlé Nutrition Workshop Clinical & Performance Program, 'Inflammatory Bowel Diseases', Pasadena, Calif., November 1998 /

, 1999
Among inflammatory bowel diseases, Crohn’s disease and ulcerative colitis are of particular importance to gastroenterologists treating both children and adults.
Bistrian, B.R.
core  

Thymulin: An emerging anti-inflammatory molecule

, 2005
Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as 'serum thymic factor' (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties.
Haddad J.J., Safieh-Garabedian B., Saade N.E.   +2 more
core   +1 more source