Results 111 to 120 of about 1,259,702 (421)
Nature Genetics, 2016 Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology.
K. D. de Lange +31 more
semanticscholar +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis [PDF]
, 2014 Background: Diet may have a role in the etiology of inflammatory bowel disease. In previous studies, the associations between increased intakes of carbohydrates, sugar, starch, and inflammatory bowel disease are inconsistent.
Abraham +83 more
core +1 more source
Optimal Estimation of Bacterial Growth Rates Based on Permuted Monotone Matrix [PDF]
Biometrika (2020), 2019 Motivated by the problem of estimating the bacterial growth rates for genome assemblies from shotgun metagenomic data, we consider the permuted monotone matrix model $Y=\Theta\Pi+Z$, where $Y\in \mathbb{R}^{n\times p}$ is observed, $\Theta\in \mathbb{R}^{n\times p}$ is an unknown approximately rank-one signal matrix with monotone rows, $\Pi \in \mathbb{
arxiv +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Inflammatory bowel disease [PDF]
Archives of Disease in Childhood, 2006 Twenty five per cent of inflammatory bowel disease presents in childhood. Growth and nutrition are key issues in the management with the aim of treatment being to induce and then maintain disease remission with minimal side effects. Only 25% of Crohn's disease presents with the classic triad of abdominal pain, weight loss, and diarrhoea.
R M, Beattie +4 more
openaire +2 more sources
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources
Unsupervised physics-informed neural network in reaction-diffusion biology models (Ulcerative colitis and Crohn's disease cases) A preliminary study [PDF]
arXiv, 2023 We propose to explore the potential of physics-informed neural networks (PINNs) in solving a class of partial differential equations (PDEs) used to model the propagation of chronic inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. An unsupervised approach was privileged during the deep neural network training.
arxiv
FEBS Open Bio, EarlyView.In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
, 2012 Cited the following: Clostridium difficile infection in patients with inflammatory bowel disease; Rheumatological manifestations in inflammatory bowel disease; Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets; AGA technical review on the
Ahmed, Kate
core