Results 91 to 100 of about 316,954 (250)

Interstitium‐Mimicking Porous Alveolar Membranes Enable Physiologic Aerosol Transport and Distinct Acute‐Chronic Lung Injury Responses

Advanced Functional Materials, EarlyView.
An interstitium‐mimicking membrane combines three‐dimensional alveolar geometry, high pore interconnectivity, and mechanical compliance to overcome transport limitations of conventional lung‐on‐chip barriers. The resulting platform supports physiologic aerosol transport, quantitative analysis of cross‐barrier particle movement, and reveals divergent ...
Jae‐Won Choi, Sheng Zhang, Abbas Jalili, August Kohls, Woo‐Youl Maeng, Sikandar Azam, Wu Liu, Barbie Varghese, Yixin Zhao, Xi Ren, Shimin Liu, Si‐Yang Zheng   +11 more
wiley   +1 more source

Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection

Frontiers in Cellular and Infection Microbiology
BackgroundThe prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored.
Chunxiang Ma, Chunxiang Ma, Chunxiang Ma, Mingshan Jiang, Mingshan Jiang, Mingshan Jiang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Zhen Zeng, Zhen Zeng, Zhen Zeng, Yushan Wu, Yushan Wu, Yushan Wu, Rui Cheng, Rui Cheng, Rui Cheng, Hao Lin, Hao Lin, Hao Lin, Jiangmei Pang, Jiangmei Pang, Jiangmei Pang, Fang Yin, Fang Yin, Fang Yin, Yongbin Jia, Yongbin Jia, Yongbin Jia, Lili Li, Lili Li, Lili Li, Hu Zhang, Hu Zhang, Hu Zhang   +35 more
doaj   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Nanofiber‐Supported Decellularized Matrix Membrane Creates a Biomimetic Biochemical and Biophysical Niche for Intestinal Organoid Epithelium

Advanced Healthcare Materials, EarlyView.
A nanofiber‐supported decellularized extracellular matrix (NaDE) membrane recreates key biochemical and mechanical features of native intestinal tissue. This platform enables the formation of a more physiologically relevant intestinal epithelium, enhancing stem cell maintenance and promoting diverse cell differentiation.
Jaeseung Youn, Hyeonji Kim, Nam Than, Juhyeok Kim, Jangwon Yoon, Dohui Kim, Hyun Jung Kim, Dong Sung Kim   +7 more
wiley   +1 more source

Immunoglobulin G4-Related Disease Masquerading as Crohn Disease, Managed by Intestinal Ultrasound: A Case Report

Annals of Internal Medicine: Clinical Cases
We present the case of a 36-year-old man initially diagnosed with Crohn disease who was nonresponsive to numerous advanced therapies. Further evaluation revealed diffuse lymphadenopathy, severe enterocolitis, and significantly elevated immunoglobulin G4 ...
Noa Krugliak Cleveland, Charlotte M. Duty, Khushi S. Bhondwe, Emma A. Picker, Reem Jan, Christopher R. Weber   +5 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Inflammatory bowel disease [PDF]

Alimentary Pharmacology & Therapeutics, 2003
Keighley, M.R., Stockbrügger, R.W.
openaire   +3 more sources

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

Colonic Tissue Expression of MAdCAM‐1 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease

Clinical and Translational Science
We assessed the predictive value of MAdCAM‐1 expression on response to vedolizumab in patients with inflammatory bowel disease. This was a retrospective, single‐center, cohort study including 109 patients with pretreatment inflammation who completed at ...
Nikhil Reddy, Jeremy A. Klein, Nikita Thomas, Dejan Micic, Zifeng Deng, David T. Rubin, Russell D. Cohen, Sushila Dalal, Britt Christensen, Haider I. Haider, Vesta Valuckaite, Katherine R. Meckel, Marc Bissonnette, Christopher R. Weber, Joel Pekow   +14 more
doaj   +1 more source