Results 111 to 120 of about 7,176,980 (297)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Frontiers in Immunology, 2019
Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial and environmental factors.
Daniela Parada-Venegas, Marjorie De la Fuente, G. Landskron, María-Julieta González, R. Quera, G. Dijkstra, H. Harmsen, K. Faber, M. Hermoso   +8 more
semanticscholar   +1 more source

The Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

, 2008
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Anti–Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely investigated ...
Papp, Mária, Lakatos, Péter László, Norman, G. L., Altorjay, István   +3 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Short-term Outcomes and Associated Factors of Postoperative Complications following Laparoscopic Ileocecal Resection in Complex Crohn's Disease

Journal of the Anus, Rectum and Colon
Objectives: Minimally invasive surgery (MIS) is widely used for Crohn's disease (CD), but its feasibility in complex CD is still debated. This study aimed to evaluate short-term outcomes and identify factors associated with major complications following ...
Eiichi Nakao, Kenji Tatsumi, Nao Obara, Koki Goto, Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei   +6 more
doaj  

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery
Aim In patients with failing ileo‐anal pouches there is often diagnostic uncertainty. In this setting, we may offer revisional pouch surgery with biologic “coverage” for presumed Crohn's disease (CD) which enables an alternative to pouch excision and end
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
doaj   +1 more source

CARMIL2 Deficiency Presenting as Very Early Onset Inflammatory Bowel Disease [PDF]

, 2019
Background: Children with very early onset inflammatory bowel diseases (VEO-IBD) often have a refractory and severe disease course. A significant number of described VEO-IBD-causing monogenic disorders can be attributed to defects in immune-related genes.
Conca, Raffaele, Jeske, Tim, Hollizeck, S, Mukhina, Anna, Meino Rohlfs, Conca, R, Yulia Rodina, Shcherbina, Anna, Muise, Aleixo M, Illig, D, Shcherbina, A, Klein, Christoph, Rodina, Y, Mukesh M Desai, Wall, Sarah, Kotlarz, D, Muise, AM, Gothe, Florian, Tim Jeske, Koletzko, Sibylle, David Illig, Snapper, SB, Rodina, Yulia, Daniel Kotlarz, Sebastian Hollizeck, Eberhard Lurz, Karacabey, N, Hauck, F, Raffaele Conca, Taur, Prasad D, Arslan, DURAN, Rohlfs, Meino, Schober, T, Mukhina, A, Koletzko, S, Neslihan Karacabey, Marquardt, Benjamin, Scott B Snapper, Hauck, Fabian, Tilmann Schober, Magg, Thomas, Anna Mukhina, Desai, Mukesh M, Vanessa Mitsialis, Wall, S, Christoph Klein, Rohlfs, M, Benjamin Marquardt, Florian Gothe, Hollizeck, Sebastian, Sarah Wall, Schober, Tilmann, Ekrem Unal, Mitsialis, Vanessa, Anna Shcherbina, Prasad D Taur, Thomas Magg, Lurz, Eberhard, Duran Arslan, Gothe, F, Klein, C, Kotlarz, Daniel, Magg, T, Aleixo M Muise, Marquardt, B, Jeske, T, Taur, PD, Karacabey, Neslihan, Illig, David, Unal, EKREM, Fabian Hauck, Snapper, Scott B, Desai, MM, Mitsialis, V, Lurz, E, Sibylle Koletzko, Klein Christoph, Shcherbina Anna, Desai Mukesh M, ARSLAN DURAN, Rodina Yulia, Gothe Florian, Hauck Fabian, Wall Sarah, Jeske Tim, Conca Raffaele, Lurz Eberhard, KARACABEY NESLİHAN, Mukhina Anna, Mitsialis Vanessa, Snapper Scott B, Koletzko Sibylle, Rohlfs Meino, Marquardt Benjamin, Muise Aleixo M, Illig David, Schober Tilmann, Taur Prasad D, ÜNAL EKREM, Hollizeck Sebastian, Kotlarz Daniel, Magg Thomas   +101 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Differential regulation of interleukin-17 and interferon-y production in inflammatory bowel disease [PDF]

, 2010
PhDBackground and Aims. Interleukin (IL)-17 is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear. Methods.
Rovedatti, Laura
core   +2 more sources

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source