Results 81 to 90 of about 371,945 (298)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

The NOD2 single nucleotide polymorphisms rs2066843 and rs2076756 are novel and common Crohn's disease susceptibility gene variants [PDF]

, 2010
Background: The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences.
Darina Czamara, Seiderer, J., Seiderer Julia, Ochsenkühn, Thomas, Laubender, R. P., Beigel, F., Rüdiger P Laubender, Laubender, R., Glas, J., Müller-Myhsok, B., Czamara, D., Bertram Müller-Myhsok, Diegelmann Julia, Tillack, Cornelia, Pfennig Simone, Brand, Stephan, Göke, B., Brand Stephan, Thomas Ochsenkühn, Olszak Torsten, Weidinger Maria, Beigel, Florian, Weidinger, Maria, Ochsenkühn, T., Jürgens, Matthias, Jürgens, M., Cornelia Tillack, Julia Diegelmann, Beigel Florian, Müller-Myhsok Bertram, Jürgens Matthias, Göke, Burkhard, Pfennig, S., Pfennig, Simone, Peter Lohse, Seiderer, Julia, Glas, Jürgen, Laubender, Rüdiger P., Diegelmann, J., Lohse, P., Ochsenkühn Thomas, Müller-Myhsok, Bertram, Weidinger, M., Rüdiger P. Laubender, Burkhard Göke, Göke Burkhard, Stephan Brand, Laubender Rüdiger P., Maria Weidinger, Brand, S., Czamara, Darina, Jürgen Glas, Tillack Cornelia, Matthias Jürgens, Czamara Darina, Lohse, Peter, Diegelmann, Julia, Simone Pfennig, Glas Jürgen, Torsten Olszak, Olszak, T., Florian Beigel, Lohse Peter, Julia Seiderer, Olszak, Torsten, Tillack, C.   +65 more
core   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

The evolving understanding of histology as an endpoint in ulcerative colitis [PDF]

Intestinal Research
A therapeutic goal for patients with ulcerative colitis (UC) is deep remission including clinical remission and mucosal healing. Mucosal healing was previously defined by endoscopic appearance, but recent studies demonstrate that histological ...
Shintaro Akiyama, Yusuke Miyatani, David T. Rubin   +2 more
doaj   +1 more source

Detecting and managing small bowel Crohn’s disease – capsule endoscopy becoming a first line diagnostic method?

, 2011
Small bowel endoscopy is crucial for diagnosing small bowel Crohn’s disease, and capsule endoscopy is complemented by balloon-assisted enteroscopy to take biopsies and by magnetic resonance imaging to visualize enteral and extra-intestinal involvement ...
Hausmann, Johannes, Albert, Jörg Gerhard   +1 more
core   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

Arthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo, Robert Fox, Katherine M. Hammitt, Julie Frantsve‐Hawley, Matthew C. Baker, Stamatina Danielides, Eduardo De Sousa, Brent P. Goodman, Jennifer K. King, Steven Mandel, Ghaith Noaiseh, Pantelis P. Pavlakis, George Sarka, R. Hal Scofield, Arun Varadhachary, Daniel J. Wallace, Matt Makara, Nancy Carteron, Steven Carsons, in collaboration with the Consensus Expert Panel (CEP) members, G. Alden Adkins, Brittany Adler, Hossein Ansari, Senada Arabelovic, Alan Baer, Denis Balaban, Shamik Bhattacharyya, Evelyn Bromet, Krishna Chaganti, Kamal Chemali, Melissa Cortez, Schartess Culpepper, Paul Dellaripa, Dana Direnzo, Daniel El Bogdadi, Robert Fearon, Mehrnez Fischbach, Judi Furlong, Christopher Gibbons, Rachael Gordon, Thomas Grader Beck, Syed Haider, Larry Hollenbeck, Chadwick R. Johr, Stuart S. Kassan, Brian King, Octavia Kincaid, Eugene Kissin, Vasileios Kyttaris, Lindsay Lally, Brandon M. Law, Janet Lewis, Scott M. Lieberman, Amanda Lusa, Joseph Lutt, Rashmi Maganti, Arthur M. Mandelin, Sara McCoy, Kerry Neall, Timothy Niewold, Anne Louise Oaklander, Ruben A. Peredo‐Wende, Lynn Petruzzi, Mark A. Porter, Guada Respicio Duque, Tania Reyna, Nathaniel M. Robbins, Elliot D. Rosenstein, Laura Rosow, Breanna Ruthrauff, Amit Sachdev, Nora Sandorfi, Sarah Schafer, Elena Schiopu, Chokkalingam Siva, Daniel Small, Sara M. Stern, Lauren Stiles, Susan Stoddard, Jinny Tavee, Donald Thomas, Edward L. Treadwell, Nagagopal Venna, Steven Vernino, Frederick B. Vivino, Brittany Weber, Sepideh Yadollahi, Huiying Yu, Scott Zashin   +88 more
wiley   +1 more source

IRGM variants and susceptibility to inflammatory bowel disease in the German population. [PDF]

, 2013
Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD susceptibility ...
Darina Czamara, Seiderer, J., Goke, B., Eleni Tsekeri (276693), Stephanie Bues, Fries, C., Julia Seiderer (107820), Beigel, F., Glas, J., Friedrich, Matthias, Christian Steib (174731), Czamara, D., Jürgen Glas (107816), Stephanie Bues (276692), Bues, S., Eleni Tsekeri, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Florian Beigel (174724), Beigel, Florian, Matthias Friedrich (174721), Stallhofer, J., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Steib, Christian, Göke, Burkhard, Fries, Christoph, Friedrich, M., Seiderer, Julia, Glas, Jürgen, Tsekeri, E., Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Martin Wetzke, Burkhard Göke, Christian Steib, Stephan Brand, Tsekeri, Eleni, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Julia Diegelmann (107830), Bues, Stephanie, Jürgen Glas, Wetzke, Martin, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten   +59 more
core   +1 more source