Results 51 to 60 of about 7,176,980 (297)

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

Genome Biology, 2012
The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system. However, the precise dysfunctions of microbial metabolism in the gastrointestinal microbiome during IBD ...
X. Morgan, T. Tickle, H. Sokol, D. Gevers, K. Devaney, D. Ward, J. Reyes, Samir A. Shah, N. LeLeiko, S. Snapper, A. Bousvaros, J. Korzenik, B. Sands, R. Xavier, C. Huttenhower   +14 more
semanticscholar   +1 more source

Global evolution of inflammatory bowel disease across epidemiologic stages

Nature
During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania1.
L. Hracs, J. Windsor, J. Gorospe, Michael Cummings, S. Coward, M. Buie, J. Quan, Q. Goddard, L. Caplan, A. Markovinović, Tyler Williamson, Yvonne Abbey, Murdani Abdullah, Maria Abreu, Vineet Ahuja, R. A. Raja Ali, Mansour Altuwaijri, D. Balderramo, Rupa Banerjee, Eric I. Benchimol, Charles N. Bernstein, E. Brunet-Mas, J. Burisch, V. H. Chong, Iris Dotan, U. Dutta, S. Elouali, A. Forbes, A. Forss, R. Gearry, V. Dao, J. Hartono, I. Hilmi, P. Hodges, Gareth-Rhys Jones, F. Juliao-Baños, J. Kaibullayeva, Paul Kelly, Taku Kobayashi, P. Kotze, P. Lakatos, C. Lees, J. Limsrivilai, Bobby Lo, Edward V. Loftus, J. Ludvigsson, Jwy Mak, Ying-Lei Miao, Ka-Kei Ng, S. Okabayashi, O. Olén, R. Panaccione, M. Paudel, A. Quaresma, D. Rubin, M. Simadibrata, Yang Sun, Hidekazu Suzuki, Martin Toro, Dan Turner, B. Iade, Shu-Chen Wei, J. Yamamoto-Furusho, Suk-Kyun Yang, S. Ng, G. Kaplan   +65 more
semanticscholar   +1 more source

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2005
The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic ...
M. Silverberg, J. Satsangi, T. Ahmad, I. Arnott, C. Bernstein, S. Brant, R. Caprilli, J. Colombel, C. Gasche, K. Geboes, D. Jewell, Amir S Karban, E. Loftus, A. Peña, R. Riddell, D. Sachar, S. Schreiber, A. Steinhart, S. Targan, S. Vermeire, B. Warren   +20 more
semanticscholar   +1 more source

Prolonged time to treatment of biologics in inflammatory bowel disease: disparities from a retrospective study in a tertiary referral centre in the UK

BMC Gastroenterology
Background Several disparities in healthcare utilisation and delivery are reported in inflammatory bowel disease (IBD). We examined disparities for delays in biologic administration.
Charlotte Wong, Paul Bassett, Nikolaos Kamperidis, Ravi Misra, Lisa Younge, Lovesh Dyall, Katie Yeung, Christy Rejee, Naila Arebi   +8 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Recent trends in the epidemiology of inflammatory bowel diseases: up or down? [PDF]

, 2006
Inflammatory bowel disease (IBD) is traditionally considered to be common in the Western world, and its incidence has sharply increased since the early 1950s.
Lakatos, Péter László
core   +1 more source

GPR65 promotes intestinal mucosal Th1 and Th17 cell differentiation and gut inflammation through downregulating NUAK2

Clinical and Translational Medicine, 2022
G protein‐coupled receptor 65 (GPR65), a susceptibility gene for inflammatory bowel diseases (IBD), has been identified to promote Th17 cell pathogenicity and induce T cell apoptosis.
Ritian Lin, Wei Wu, Huimin Chen, Han Gao, Xiaohan Wu, Gengfeng Li, Qiong He, Huiying Lu, Mingming Sun, Zhanju Liu   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluation of changes in intestinal microbiota in Crohn’s disease patients after anti-TNF alpha treatment

Scientific Reports, 2021
Intestinal dysbiosis is key in the onset and development of Crohn’s disease (CD). We evaluated the microbiota changes in CD patients before and after a six-month anti-TNF treatment, comparing these changes with the microbiota of healthy subjects.
Laura Sanchis-Artero, Juan Francisco Martínez-Blanch, Sergio Manresa-Vera, Ernesto Cortés-Castell, Marina Valls-Gandia, Marisa Iborra, Jose Maria Paredes-Arquiola, Maia Boscá-Watts, Jose Maria Huguet, Rafael Gil-Borrás, Josefa Rodríguez-Morales, Xavier Cortés-Rizo   +11 more
doaj   +1 more source