Results 51 to 60 of about 371,945 (298)

Faecal haemoglobin and faecal calprotectin as indicators of bowel disease in patients presenting to primary care with bowel symptoms [PDF]

, 2015
Objective In primary care, assessing which patients with bowel symptoms harbour significant disease (cancer, higher-risk adenoma or IBD) is difficult.
Wilson, Robyn, Carey, Francis A., Fraser, Callum G/, Steele, Robert J. C., Mowat, Craig; id_orcid, Digby, Jayne; id_orcid, Strachan, Judith A.   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Enterogenous Microbiotic Markers in the Differential Diagnosis of Crohn’s Disease and Intestinal Tuberculosis

Frontiers in Immunology, 2022
Crohn’s disease (CD) is a chronic intestinal disorder characterized by refractory gastrointestinal ulcerations. Intestinal tuberculosis (ITB) is one common intestinal disease in east Asia.
Mingshan Jiang, Mingshan Jiang, Mingshan Jiang, Zhen Zeng, Zhen Zeng, Zhen Zeng, Kexin Chen, Kexin Chen, Kexin Chen, Yuan Dang, Yuan Dang, Yuan Dang, Lili Li, Lili Li, Lili Li, Chunxiang Ma, Chunxiang Ma, Chunxiang Ma, Rui Cheng, Rui Cheng, Rui Cheng, Kehan Hu, Kehan Hu, Kehan Hu, Xi Li, Xi Li, Xi Li, Hu Zhang, Hu Zhang, Hu Zhang   +29 more
doaj   +1 more source

The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease. [PDF]

, 2012
Recent molecular studies have revealed a highly complex bacterial assembly in the canine intestinal tract. There is mounting evidence that microbes play an important role in the pathogenesis of acute and chronic enteropathies of dogs, including ...
Toresson, Linda, Jörg M. Steiner (107366), Ivan Ivanov, Dillman, Enricka M., Enricka M Dillman, Ivanov, Ivan, Stefan Unterer (107353), Heimesaat, Markus M., García Mazcorro, José Francisco, Jan S. Suchodolski (107343), Romy M Heilmann, Markel, Melissa E., Enricka M. Dillman (107363), Linda Toresson (107370), Melissa E Markel, Markel, Melissa, Linda Toresson, Steiner, J��rg M., Audrey K. Cook (107368), Cook, Audrey K., Jan S Suchodolski, Minamoto, Yasushi, Jörg M Steiner, Garcia-Mazcorro, Jose F., Priyanka Kachroo, Scot E. Dowd (107356), Heilmann, Romy M., Dowd, Scot E., Yasushi Minamoto, Jose F. Garcia-Mazcorro (107351), Unterer, Stefan, Romy M. Heilmann (107355), Jose F Garcia-Mazcorro, Stefan Unterer, Yasushi Minamoto (107360), Scot E Dowd, Audrey K Cook, Ivan Ivanov (107359), Melissa E. Markel (107347), Priyanka Kachroo (107357), Kachroo, Priyanka, Steiner, Jörg M., Suchodolski, Jan S.   +42 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identification of areas of functioning and disability addressed in Inflammatory bowel disease-specific patient reported outcome measures [PDF]

, 2012
Inflammatory Bowel Disease (IBD) is a chronic disabling disease of the gastrointestinal tract. The disease is strongly associated with limited performance of everyday activities and restrictions in work and employment, recreation and relationships to ...
Achleitner, Ulrike
core  

Clinical presentation of Crohn's disease. Association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery

, 2005
Background/Aims: Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically ...
Gasztonyi, Beáta, Kovács, Attila, Figler, Mária, Szalay, Ferenc, Cseh, J., Mikó, Éva, Horváth, Gábor, Szekeres Barthó, J., Papp, János, Lakatos, Péter László, Molnár, Tamás, Kovács, Ágota, Lakatos, Péter, Hunyady, Béla, Tulassay, Zsolt, Kisbenedek, A. G., Lakatos, László   +16 more
core   +1 more source

Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients [PDF]

, 2003
The recent identification of the CARD15/NOD2 gene as a susceptibility locus for Crohn's disease represents an important step towards the delineation of the immuno-pathogenesis of inflammatory bowel disease.
Folwaczny, Christian, Török, H. P., Lohse, P., Glas, J.   +3 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source