Results 131 to 140 of about 948,572 (352)

Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases.

World journal of gastrointestinal pharmacology and therapeutics, 2016
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result from an abnormal immune response against endogenous flora and luminal ...
I. Soufli, R. Toumi, H. Rafa, C. Touil-Boukoffa   +3 more
semanticscholar   +1 more source

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

Gastroenterology, 2020
BACKGROUND The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients.
D. Turner, A. Ricciuto, Ayanna E. Lewis, F. D'amico, J. Dhaliwal, A. Griffiths, D. Bettenworth, W. Sandborn, B. Sands, W. Reinisch, J. Schölmerich, W. Bemelman, S. Danese, J. Mary, D. Rubin, J. Colombel, L. Peyrin-Biroulet, I. Dotan, M. Abreu, A. Dignass   +19 more
semanticscholar   +1 more source

HMGB1 Derived from the Pyroptotic Microenvironment Promotes Macrophage Extracellular Traps in Hirschsprung‐Associated Enterocolitis

Advanced Biology, EarlyView.
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang, Jing Li, Lili Song, Liya Pan, Chengchen Zhang, Zhiyan Zhan, Li Hong   +6 more
wiley   +1 more source

Overcoming cancer risk in inflammatory bowel disease: new insights into preventive strategies and pathogenesis mechanisms including interactions of immune cells, cancer signaling pathways, and gut microbiota

Frontiers in Immunology
Inflammatory bowel disease (IBD), characterized primarily by gastrointestinal inflammation, predominantly manifests as Crohn’s disease (CD) and ulcerative colitis (UC).
Haonan Zhang, Yulu Shi, Chanchan Lin, Chengcheng He, Shanping Wang, Qingyuan Li, Yan Sun, Mingsong Li   +7 more
doaj   +1 more source

Histopathology of the gut in rheumatic diseases [PDF]

, 2018
The gastrointestinal tract regulates the trafficking of macromolecules between the environment and the host through an epithelial barrier mechanism and is an important part of the immune system controlling the equilibrium between tolerance and immunity ...
Ciccia F., Ferrante A., Guggino G., Macaluso F., Rizzo A.   +4 more
core   +1 more source

CONAN: Complementary Pattern Augmentation for Rare Disease Detection [PDF]

arXiv, 2019
Rare diseases affect hundreds of millions of people worldwide but are hard to detect since they have extremely low prevalence rates (varying from 1/1,000 to 1/200,000 patients) and are massively underdiagnosed. How do we reliably detect rare diseases with such low prevalence rates?
arxiv  

In Search of Newer Targets for IBD: A Systems and a Network Medicine Approach [PDF]

arXiv, 2020
Introduction: Crohn's disease and ulcerative colitis, both under the umbrella of inflammatory bowel diseases (IBD), involve many distinct molecular processes. The difference in their molecular processes is studied by using the different genes involved in each disease, and it is explored further for drug targeting and drug repurposing.
arxiv  

Inflammatory Bowel Diseases: Review of Known Environmental Protective and Risk Factors Involved.

Inflammatory Bowel Diseases, 2017
Inflammatory bowel diseases consisting of Crohn's disease and ulcerative colitis are chronic inflammatory diseases of the gastrointestinal tract. In addition to genetic susceptibility and disturbances of the microbiome, environmental exposures forming ...
K. V. D. van der Sloot, M. Amini, V. Peters, G. Dijkstra, B. Alizadeh   +4 more
semanticscholar   +1 more source

A Novel Protein‐Polysaccharide Oral Nanoemulsion Targeting Activated Hepatic Stellate Cells to Enhance the Therapeutic Effect of Pirfenidone on Fibrosis After Transarterial Chemoembolization for Liver Cancer

Advanced Functional Materials, EarlyView.
Transarterial Chemoembolization (TACE) may aggravate liver fibrosis. In this study, a novel oral targeting nanoemulsion is fabricated to enhance the therapeutic effect of antifibrotic drug‐pirfenidone (PFD) on fibrosis after TACE. Studies have shown that PFD nanoemulsion can enhance the oral liver targeting effect of PFD, and effectively improve the ...
Zhimei Cheng, Shan Xu, Yi Lei, Huizhou He, Runbin Sun, Xingle Jin, Cheneryu Huang, Yuhao Zheng, Jianqing Peng, Lei Tang, Peng Luo, Yi Chen, Shuai Zhang   +12 more
wiley   +1 more source

Clinical Practice Guidelines for the Medical Management of Nonhospitalized Ulcerative Colitis: The Patient Perspective

Canadian Journal of Gastroenterology and Hepatology, 2015
A series of clinical practice guidelines were recently developed by the Canadian Association of Gastroenterology (CAG) to provide clinicians with recommendations for the medical management of nonhospitalized ulcerative colitis (UC) patients.
A Hillary Steinhart, Aida Fernandes
doaj   +1 more source