Results 161 to 170 of about 3,225,863 (285)

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood

Journal of Inflammation Research
Taegyu Kim,1 Paola Nicoletti,1 Maria Manuela Estevinho,2,3 Leonid Tarassishin,1 Mellissa Picker,1 Anketse Debebe,1 Isabella Nguyen,1 Rhiannon Dutra-Clarke,4 Courtney Young,4 Joanne Stone,5 Ariella Bar-Gil Shitrit,6 Manasi Agrawal,7 Jean-Frederic Colombel,
Kim T, Nicoletti P, Estevinho MM, Tarassishin L, Picker M, Debebe A, Nguyen I, Dutra-Clarke R, Young C, Stone J, Bar-Gil Shitrit A, Agrawal M, Colombel JF, Torres J, Ng SC, Zhang L, McGovern DPB, Peter I   +17 more
doaj  

Intestinal Ultrasound-Guided Precision Medicine in Inflammatory Bowel Diseases: A Narrative Review. [PDF]

J Pers Med
Clelia C, Fanizzi F, Dal Buono A, Faggiani I, D'Amico F, Zilli A, Parigi TL, Solitano V, Furfaro F, Massironi S, Armuzzi A, Danese S, Allocca M.   +12 more
europepmc   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Extranodal NK/T-cell lymphoma: An unexpected cause of postoperative fever in a young male

Asian Journal of Surgery, 2021
Wenhao Chen, Junjie Zhou, Congqing Jiang, Qun Qian, Zhao Ding   +4 more
doaj   +1 more source

Editorial: Biomarkers and beyond: predicting course and tailoring treatment in inflammatory bowel diseases. [PDF]

Front Immunol
Dal Buono A, Nardone OM, Ferreiro-Iglesias R.   +2 more
europepmc   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Special Issue "Drugs in Inflammatory Bowel Diseases". [PDF]

Int J Mol Sci
D'Antongiovanni V, Bernardini N, Pellegrini C.   +2 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Mcl1 as a Molecular Switch Linking Inflammatory Bowel Diseases to Colorectal Tumorigenesis. [PDF]

Biomolecules
Elshazly AM, Li J, Yang GY, Radhakrishnan SK.   +3 more
europepmc   +1 more source