Results 171 to 180 of about 3,411,578 (286)

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Cancer Risk With Advanced Therapies in Patients With Inflammatory Bowel Diseases: An Administrative Claims-Based Study. [PDF]

Clin Gastroenterol Hepatol
Ahuja D, Yeh KH, Park SK, Qi Y, Patel SB, Goodwin SW, Vuyyuru SK, Malik TA, Ramos GP, Silverman A, Singh N, Olen O, Ananthakrishnan AN, Jairath V, Xu R, Singh S.   +15 more
europepmc   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Epigenetic biomarkers in inflammatory bowel diseases-computational challenges and opportunities. [PDF]

J Crohns Colitis
Lee S, Park J, Lee HC, Xu X, Slater E, Gasparetto M, Han N, Zilbauer M.   +7 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood

Journal of Inflammation Research
Taegyu Kim,1 Paola Nicoletti,1 Maria Manuela Estevinho,2,3 Leonid Tarassishin,1 Mellissa Picker,1 Anketse Debebe,1 Isabella Nguyen,1 Rhiannon Dutra-Clarke,4 Courtney Young,4 Joanne Stone,5 Ariella Bar-Gil Shitrit,6 Manasi Agrawal,7 Jean-Frederic Colombel,
Kim T, Nicoletti P, Estevinho MM, Tarassishin L, Picker M, Debebe A, Nguyen I, Dutra-Clarke R, Young C, Stone J, Bar-Gil Shitrit A, Agrawal M, Colombel JF, Torres J, Ng SC, Zhang L, McGovern DPB, Peter I   +17 more
doaj  

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier. [PDF]

Curr Opin Gastroenterol
Ciorba MA.
europepmc   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Survival analysis in brazilian cohort: impact of biological therapy in disease duration until surgery

, 2017
The indications for biological agents in Crohn’s Disease (CD) are mainly focused on the severe forms of the disease. Frequently, a patient needs some form of surgical treatment during the use of this class of medications.
Saab, Barbara, Kotze, Lorete, Magro, Daniela, Martinez, Carlos Augusto, Saab, Mansur, Kotze, Paulo, Pinheiro, Lilian, Ayrizono, Maria de Lourdes, Olandoski, Marcia, Coy, Claudio   +9 more
core  

Comparative Risk of Serious Infections With Biologic Agents and Oral Small Molecules in Inflammatory Bowel Diseases: 2026 Update. [PDF]

Gastroenterology
Solitano V, Silverman A, Miyatani Y, Ahuja D, Jairath V, Singh S, IBD PHARMACOEPIDEMIOLOGY GROUP.   +6 more
europepmc   +1 more source