Results 171 to 180 of about 380,200 (294)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Inflammatory bowel diseases: pathological mechanisms and therapeutic perspectives. [PDF]

Mol Biomed
Yang X, Guo H, Zou M.
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood

Journal of Inflammation Research
Taegyu Kim,1 Paola Nicoletti,1 Maria Manuela Estevinho,2,3 Leonid Tarassishin,1 Mellissa Picker,1 Anketse Debebe,1 Isabella Nguyen,1 Rhiannon Dutra-Clarke,4 Courtney Young,4 Joanne Stone,5 Ariella Bar-Gil Shitrit,6 Manasi Agrawal,7 Jean-Frederic Colombel,
Kim T, Nicoletti P, Estevinho MM, Tarassishin L, Picker M, Debebe A, Nguyen I, Dutra-Clarke R, Young C, Stone J, Bar-Gil Shitrit A, Agrawal M, Colombel JF, Torres J, Ng SC, Zhang L, McGovern DPB, Peter I   +17 more
doaj  

Impact of Endometriosis on the Progression of Inflammatory Bowel Diseases: A Multicenter Retrospective Study. [PDF]

Clin Transl Gastroenterol
Guillo L, El Oumami O, Seksik P, Le Cosquer G, Méheut L, Abitbol V, Nancey S, Buisson A, Uzzan M, Vidon M, Caillo L, Caron B, Benezech A, Atanasiu C, Richard N, Nuzzo A, Le Berre C, Bourrier A, Reenaers C, Labreuche J, Serrero M, Rubod C, Wils P.   +22 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Extranodal NK/T-cell lymphoma: An unexpected cause of postoperative fever in a young male

Asian Journal of Surgery, 2021
Wenhao Chen, Junjie Zhou, Congqing Jiang, Qun Qian, Zhao Ding   +4 more
doaj   +1 more source

Nutrigenomics and Epigenetics in the Dietary Management of Inflammatory Bowel Diseases. [PDF]

Genes (Basel)
Musz P, Ryś G, Fic W, Sokal-Dembowska A, Jarmakiewicz-Czaja S.   +4 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Non-Responders to Biologic Disease Modifying Antirheumatic Treatment for Inflammatory Bowel Diseases. [PDF]

Mediators Inflamm
Gadzhanova S, Roughead E.
europepmc   +1 more source