Results 191 to 200 of about 437,829 (320)

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

Roles of Deubiquitinases OTUD3 and OTUD5 in Inflammatory Bowel Diseases. [PDF]

Int J Mol Sci
Watanabe T, Kudo M.
europepmc   +1 more source

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Chemerin as a biomarker of inflammatory bowel diseases: a meta-analysis. [PDF]

BMC Gastroenterol
Tian Z, Xiang Q, Long M, Liao J, Wang F, Li X.   +5 more
europepmc   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Off-label use of thalidomide in children with Crohn's disease and inflammatory bowel diseases. [PDF]

Einstein (Sao Paulo)
Fonseca LB, Drummond PLM, Silva CA, de Pádua CAM.   +3 more
europepmc   +1 more source

P104 Defective metabolism mediates NK cell dysfunction in inflammatory bowel disease (IBD) [PDF]

, 2020
Vanessa Zaiatz-Bittencourt, Elizabeth J. Ryan, F. G. Jones, Glen Doherty   +3 more
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood

Journal of Inflammation Research
Taegyu Kim,1 Paola Nicoletti,1 Maria Manuela Estevinho,2,3 Leonid Tarassishin,1 Mellissa Picker,1 Anketse Debebe,1 Isabella Nguyen,1 Rhiannon Dutra-Clarke,4 Courtney Young,4 Joanne Stone,5 Ariella Bar-Gil Shitrit,6 Manasi Agrawal,7 Jean-Frederic Colombel,
Kim T, Nicoletti P, Estevinho MM, Tarassishin L, Picker M, Debebe A, Nguyen I, Dutra-Clarke R, Young C, Stone J, Bar-Gil Shitrit A, Agrawal M, Colombel JF, Torres J, Ng SC, Zhang L, McGovern DPB, Peter I   +17 more
doaj  

Extranodal NK/T-cell lymphoma: An unexpected cause of postoperative fever in a young male

Asian Journal of Surgery, 2021
Wenhao Chen, Junjie Zhou, Congqing Jiang, Qun Qian, Zhao Ding   +4 more
doaj   +1 more source