Results 211 to 220 of about 1,070,166 (331)

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Bromodomain-containing 4 as a therapeutic target in inflammatory bowel diseases and colorectal cancer. [PDF]

Front Pharmacol
Marafini I, Frascatani R, Colella M, De Cristofaro E, Monteleone G.   +4 more
europepmc   +1 more source

EFSUMB Recommendations and Clinical Guidelines for Intestinal Ultrasound (GIUS) in Inflammatory Bowel Diseases

Ultraschall in der Medizin - European Journal of Ultrasound, 2018
G. Maconi, K. Nylund, T. Ripollés, E. Calabrese, K. Dirks, C. Dietrich, A. Hollerweger, I. Sporea, A. Saftoiu, C. Maaser, T. Hausken, A. Higginson, D. Nürnberg, N. Pallotta, L. Romanini, C. Serra, O. Gilja   +16 more
semanticscholar   +1 more source

COVID-19 Outcomes Among Racial and Ethnic Minority Individuals With Inflammatory Bowel Disease in the United States

Manasi Agrawal, Erica J. Brenner, Joyce Wing Yan Mak, Xian Zhang, Gilaad G. Kaplan, Siew C. Ng, Walter Reinisch, Flávio Steinwurz, James D. Lewis, Michele Kissous-Hunt, Irene Modesto, Ryan C. Ungaro, Jean‐Frédéric Colombel, Michael D. Kappelman   +13 more
openalex   +1 more source

Biological therapy for dermatological manifestations of inflammatory bowel disease

, 2013
Maddalena Zippi
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

Inflammatory bowel diseases and the low-FODMAP diet: benefits and challenges in therapy. [PDF]

Front Nutr
Skoracka K, Ratajczak-Pawłowska AE, Marciniak M, Rychter AM, Szwarc K, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I.   +7 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

The multifaceted role of sirtuins in inflammatory bowel diseases. [PDF]

Am J Physiol Gastrointest Liver Physiol
Samant SA, Hyoju SK, Alverdy JC, Gupta MP.   +3 more
europepmc   +1 more source

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

Advanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou, Xianfei Wang, Teng Ben, Chunping Zhu, Xinlong Lin, Yinmu Li, Xinyue Zhang, Yeling Chen, Yuchen Xuan, Huaiwen Chen, Ke Liu, Fang Wu, Yuexin Ren, Gao Tan   +13 more
wiley   +1 more source