Results 191 to 200 of about 66,787 (287)

Direct AMPK Activation Confers Mutation‐Independent Therapeutic Benefit in Duchenne Muscular Dystrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is a severe, life‐limiting neuromuscular disorder (NMD) characterized by progressive muscle wasting and mitochondrial dysfunction. Although gene therapies offer promise, even those already approved by regulatory agencies, their use remains constrained by mutation specificity, delivery challenges and
Sean Y. Ng, Andrew I. Mikhail, Stephanie R. Mattina, Magda A. Lesinski, Irena A. Rebalka, Sophie I. Hamstra, Donald Xhuti, Val A. Fajardo, Mark A. Tarnopolsky, Joshua P. Nederveen, Gregory R. Steinberg, Thomas J. Hawke, Vladimir Ljubicic   +12 more
wiley   +1 more source

Clinical Significance and Correlation of Plasma D-Dimer, Fibrinogen, and Cytokines in Idiopathic Inflammatory Myopathy. [PDF]

Int J Gen Med
Jiang X, Shang L, Hou C.
europepmc   +1 more source

Largely Distinct Post‐Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Skeletal muscle wasting and weakness are prominent disease features. Originally considered to arise from common transcriptional changes, recent analyses demonstrated that different stimuli induce muscle wasting via largely distinct mRNA and protein changes.
Anna Stephan, Flavia A. Graca, Suresh Poudel, Yingxue Fu, Yong‐Dong Wang, Myriam Labelle, Fabio Demontis   +6 more
wiley   +1 more source

Clinical, functional, and computed tomographic characterization of idiopathic inflammatory myopathy-associated interstitial lung disease: a retrospective cohort study. [PDF]

J Bras Pneumol
Oliveira Filho JRB, Costa AN, Baldi BG, Wanderley M, Sawamura MVY, Kairalla RA.   +5 more
europepmc   +1 more source

Rethinking Statin Dosage in Coronary Disease

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Simon B. Dimmitt, Hans G. Stampfer, Michael C. Kennedy, Jennifer H. Martin   +3 more
wiley   +1 more source

Longitudinal change of idiopathic inflammatory myopathy-associated interstitial lung disease on high-resolution computed tomography, a prospective cohort study. [PDF]

BMC Pulm Med
Qiang Y, Wang H, Ni Y, Wang J, Liu A, Du J, Xi L, Hu Y, Ren Y, Xie B, Wang S, Geng J, Liu M, Dai H.   +13 more
europepmc   +1 more source

Steroid‐Refractory Cryptogenic Organising Pneumonia (COP) in a Patient With Mannose‐Binding Lectin (MBL) Deficiency

Respirology Case Reports, Volume 14, Issue 2, February 2026.
A 67‐year‐old man with cryptogenic organising pneumonia developed recurrent relapses despite corticosteroid and mycophenolate therapy. A complete absence of mannose‐binding lectin was identified, suggesting impaired apoptotic cell clearance as a contributor to persistent inflammation.
Ilias E. Dimeas, Sotirios I. Sinis, Paraskevi Kirgou, Cormac McCarthy, Zoe Daniil   +4 more
wiley   +1 more source

Cardiac involvement in established idiopathic inflammatory myopathy assessed by cardiac magnetic resonance mapping. [PDF]

Clin Rheumatol
Yurchenko K, Højgaard P, Pecini R, Korsholm SS, Diederichsen ACP, Lindhardsen J, Søndergaard E, Haue AD, Søltoft K, Jacobsen S, Diederichsen LP.   +10 more
europepmc   +1 more source

Mechanistic Insights Into NFIX‐Mediated DNA Recognition and Transcriptional Regulation in Skeletal Muscle

Smart Medicine, Volume 5, Issue 1, February 2026.
An atomic view of the NFIX–DNA complex reveals recognition of the TGGCA motif and links sequence‐specific binding to the transcriptional programs governing skeletal muscle development and disease. ABSTRACT Skeletal muscle is essential for voluntary movement and exhibits a remarkable capacity for regeneration following injury.
Ci Zhu, Shuang Liu, Xi Chen, Chengxiao Qin, Yueyu Wang, Chunchun Xue, Lingxing Li, Wenlan Du, Xin Chen, Xiaofeng Li, Jie Shen, He Song   +11 more
wiley   +1 more source

Cardiac Magnetic Resonance Imaging Markers in Idiopathic Inflammatory Myopathy - A Prospective Observational Study. [PDF]

Ann Indian Acad Neurol
Samim MM, Barthur A, Vengalil S, Nashi S, Menon D, Ganga K, Gutta BK, Jadhao AN, Baskar D, Tiwari R, Manu SG, Nittur V, Thomas PT, Sathyaprabha TN, Nalini A.   +14 more
europepmc   +1 more source