Results 251 to 260 of about 2,640,164 (297)

Optogenetic Neuromodulation in Inflammatory Pain

Neuroscience
Inflammatory pain is one of the most prevalent forms of pain and negatively influences the quality of life. Neuromodulation has been an expanding field of pain medicine and is accepted by patients who have failed to respond to several conservative treatments.
Yanan Liang, Yaping Zhou, Md. Moneruzzaman, Yonghui Wang   +3 more
openaire   +2 more sources

Local control of inflammatory pain

Agents and Actions, 1981
The mechanism of the local hyperalgesic action of prostaglandin E2 has been studied using rat paw oedema. Prostaglandin E2 is a metabotropic transmitter, activating adenylate cyclase, either directly or through the release of a stimulatory protein factor. This activation of adenylate-cyclase is blocked, locally, by opiates.
openaire   +2 more sources

Aceclofenac in the management of inflammatory pain

Expert Opinion on Pharmacotherapy, 2004
Aceclofenac (Almirall Prodesfarma SA) is an oral NSAID that is effective in the treatment of painful inflammatory diseases and has been used to treat > 75 million patients worldwide. It has proved as effective as diclofenac, naproxen and piroxicam in patients with osteoarthritis, diclofenac, ketorolac, tenoxicam and indomethacin in patients with ...
openaire   +2 more sources

Electrophysiological Mechanisms in Inflammatory Pain

1991
Inflammatory pain is mediated from the periphery by a specialized subgroup of nerve fibers, the nociceptors. The nociceptive nerve endings undergo sensitization and excitation when stimulated with inflammatory agents. It will be shown that a multitude of substances cooperates in this process.
openaire   +2 more sources

NGF as a mediator of inflammatory pain

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1996
Abstract The chapter reviews some of recent evidence which suggests that one neurotrophin, nerve growth factor (NGF), is a peripherally produced mediator of some persistent pain states, notably those associated with inflammation. The evidence for this proposal is as follows. 1.
openaire   +2 more sources

Mechanisms of Inflammatory Pain

JCR: Journal of Clinical Rheumatology, 2004
The study and treatment of clinical pain has historically identified particular pain syndromes and linked their etiology with disease factors. Missing in this approach is consideration of the mechanisms accounting for the pain that is experienced by the patient.
openaire   +2 more sources

Physiological, Inflammatory and Neuropathic Pain

1987
The confusion amongst clinicans and basic scientists as to what precisely pain is, is emblematic of the difficulties that confront all who attempt to elucidate its pathogenesis. A major contributor to this state of affairs would appear to have been Charles Sherrington. At the turn of the century, with great insight, he focussed attention away from pain
openaire   +2 more sources

Inflammatory back pain

2016
Inflammatory back pain (IBP) refers to a collection of symptoms that may help identify patients with possible inflammatory spinal disease. A number of criteria sets have been proposed for IBP, which share common features such as: onset of symptoms aged <40 years, alternating buttock pain, improvement with exercise, worsening with rest, gradual onset,
Stefan Siebert, Sengupta Raj, Alexander Tsoukas   +2 more
openaire   +1 more source

Pain and Inflammatory Mediators

1978
Pain and hyperalgesia are common features of the inflammatory process. Some pain arises as an immediate sensation after tissue injury, due to direct stimulation of sensory nerve endings. Another component arises with the inflammation which ensues after injury; the pain which then develops is a combination of mechanical and chemical stimulation due to ...
S. Moncada, S. H. Ferreira, J. R. Vane
openaire   +1 more source

Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Neuron, 2022
Judith Prado, Sabine Versteeg, William Khoury-Hanold   +2 more
exaly