Results 71 to 80 of about 1,024,092 (310)

GDNF‐RET signaling drives pulmonary neuroendocrine cell hyperplasia and allergic airway inflammation

FEBS Letters, EarlyView.
A neuroimmune interaction centered on the PNEC‐ILC2 axis in an asthma model. PNEC‐derived CGRP activates nearby ILC2s, which then release cytokines, including IL‐5 and IL‐13. These cytokines promote eosinophil and macrophage infiltration. Subsequently, GDNF produced by these cells induces PNEC hyperplasia via the GDNF receptors, RET and GFRα1 ...
Tasuku Kawano, Erina Ike, Suguru Okada, Tomoko Takahashi   +3 more
wiley   +1 more source

Intravenous Administration of Pyroglutamyl Apelin-13 Alleviates Murine Inflammatory Pain via the Kappa Opioid Receptor

Frontiers in Neuroscience, 2020
Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma.
Shuangyu Lv, Xiaomei Zhang, Yu Feng, Yuchen Zhou, Binbin Cui, Yanjie Yang, Xinchun Wang   +6 more
doaj   +1 more source

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]

, 2015
Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi, Christiansen, Blaine, Emami, Shahin, Goudarzi, Ramin   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

TRPA1 Antagonists for Pain Relief

Pharmaceuticals, 2018
Here, we review the literature assessing the role of transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable non-selective cation channel, in various types of pain conditions.
Ari Koivisto, Niina Jalava, Raymond Bratty, Antti Pertovaara   +3 more
doaj   +1 more source

Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature [PDF]

, 2016
Background: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms ...
Allan, R., Dell'Isola, A., Marreiros, S.S.P., Smith, S.L., Steultjens, Martijn   +4 more
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Transcriptomics Analysis of Porcine Caudal Dorsal Root Ganglia in Tail Amputated Pigs Shows Long-Term Effects on Many Pain-Associated Genes

Frontiers in Veterinary Science, 2019
Tail amputation by tail docking or as an extreme consequence of tail biting in commercial pig production potentially has serious implications for animal welfare. Tail amputation causes peripheral nerve injury that might be associated with lasting chronic
Dale A. Sandercock, Mark W. Barnett, Jennifer E. Coe, Alison C. Downing, Ajit J. Nirmal, Pierpaolo Di Giminiani, Sandra A. Edwards, Tom C. Freeman   +7 more
doaj   +1 more source

An evaluation of seasonal variations in footwear worn by adults with inflammatory arthritis: a cross-sectional observational study using a web-based survey [PDF]

, 2014
Background: Foot problems are common in adults with inflammatory arthritis and therapeutic footwear can be effective in managing arthritic foot problems. Accessing appropriate footwear has been identified as a major barrier, resulting in poor adherence
A Brenton-Rule, A Bryman, A Williams, A Williams, AB Dufour, AE Williams, AE Williams, AE Williams, AE Williams, AE Williams, AJ Oppenheimer, Angela Brenton-Rule, B Alcacer-Pitarch, DD Nulty, E Hyslop, E Roddy, Georgina Barr, GJ Hendry, Gordon J Hendry, H Holman, HB Menz, HB Menz, J Woodburn, JR Kirwan, K Hennessy, K Rome, K Rome, K Rome, K Rome, K Rome, K Rome, Keith Rome, MJ Spink, N Martini, P Borman, P Helliwell, R Dahmen, RN Silvester, S Naidoo, S Otter, SA Wright, T Heiberg, VM Sue   +42 more
core   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source