Results 61 to 70 of about 2,640,164 (297)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis

Frontiers in Immunology, 2022
Chronic pain, such as persistent inflammatory pain, remains a public health problem that has no effective treatment at present. Bromodomain-containing protein 4 (BRD4) inhibition, induced by JQ1 injection or BRD4 knockdown, has been used to attenuate ...
Tong Hua, Haowei Wang, Xiaoyi Fan, Ni An, Jian Li, Honghao Song, Erliang Kong, Yongchang Li, Hongbin Yuan, Hongbin Yuan   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Investigation of the central molecular events that maintain persistent inflammatory pain states. [PDF]

, 2007
Noxious stimulation of the periphery leads to long-term changes in the excitability of dorsal horn neurons of the spinal cord. In the spinal cord the increased excitability of dorsal horn neurons requires the activation of a subset of superficial dorsal ...
Wong, Y.M.
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn

Frontiers in Molecular Neuroscience, 2023
ObjectiveIntense inflammation may result in pain, which manifests as spinal central sensitization. There is growing evidence that purinergic signaling plays a pivotal role in the orchestration of pain processing.
László Ducza, Andrea Gajtkó, Krisztina Hegedűs, Erzsébet Bakk, Gréta Kis, Botond Gaál, Roland Takács, Péter Szücs, Klára Matesz, Krisztina Holló   +9 more
doaj   +1 more source

KCNQ/M currents in sensory neurons: Significance for pain therapy [PDF]

, 2003
Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic pain. M currents [I-K(M)] play a key role in regulating neuronal excitability, and mutations in neuronal KCNQ2/3 subunits, the molecular correlates of I-K(M), have ...
Main, M, Matthews, EA, Burbidge, SA, Brown, TA, Brown, DA, Passmore, GM, Marsh, SJ, Mistry, M, Selyanko, AA, Al-Qatari, M, Dickenson, AH   +10 more
core  

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]

, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J., Martina Kurejova, Thomas Kuner, Irmgard Tegeder (179372), Hu, S.J., Kurejova Martina, Bali, K.K., Agarwal, Nitin, Anke Tappe-Theodor, Bali, Kiran Kumar, Polgar Erika, Franz Hofmann (179398), Todd, A.J., Lewin, G., Kuner Thomas, Ceng Luo (179354), Feil, Robert, Jens Schlossmann, Polgar, E., Gangadharan Vijayan, Andrew J Todd, Kurejova, Martina, Feil, Susanne, Ceng Luo, Hu, S., Susanne Feil (179376), Andrew J. Todd (179384), Feil, R., Rohini Kuner (179428), Erika Polgar (5649442), Rohini Kuner, Hu, San-Jue, Liu Da-Lu, Liu, D., Kuner, Thomas, San-Jue Hu (179417), Feil, S., Tegeder, Irmgard, Tappe-Theodor Anke, Kuner, R., Nitin Agarwal (179363), Robert Feil (28669), Agarwal, N., Agarwal Nitin, Xie, R.G., Robert Feil, Kiran Kumar Bali (179358), Da-Lu Liu (179408), Erika Polgar, Kuner, T., Tappe, Anke, Gary Lewin (179380), Liu, Da-Lu, Xie, R. G., Jens Schlossmann (179389), Nitin Agarwal, Luo, Ceng, Luo, C., Vijayan Gangadharan, Hu, S. J., Xie, Rou-Gang, Hofmann Franz, Da-Lu Liu, Rou-Gang Xie (179362), Bali Kiran Kumar, Tappe-Theodor, A., Kuner, Rohini, Lewin Gary, Liu, D. L., Kiran Kumar Bali, Irmgard Tegeder, Polgár, Erika, Hofmann, Franz, Tegeder Irmgard, Vijayan Gangadharan (179356), Rou-Gang Xie, Schlossmann Jens, Franz Hofmann, Feil Susanne, Hu San-Jue, San-Jue Hu, Xie Rou-Gang, Gangadharan, Vijayan, Todd Andrew J., Feil Robert, Martina Kurejova (179365), Bali, K. K., Gary Lewin, Susanne Feil, Anke Tappe-Theodor (179367), Lewin, Gary R., Schlossmann, Jens, Liu, D.L., Thomas Kuner (162293), Schlossmann, J., Luo Ceng, Gangadharan, V., Hofmann, F., Kuner Rohini, Todd, Andrew J., Xie, R., Tegeder, I., Kurejova, M., Luo, C;Gangadharan, V;Bali, KK;Xie, RG;Agarwal, N;Kurejova, M;Tappe-Theodor, A;Tegeder, I;Feil, S;Lewin, G;Polgar, E;Todd, AJ;Schlossmann, J;Hofmann, F;Liu, DL;Hu, SJ;Feil, R;Kuner, T;Kuner, R   +103 more
core   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Phospholipase Cβ3 Expressed in Mouse DRGs is Involved in Inflammatory and Postoperative Pain

Journal of Pain Research, 2020
Susumu Ide,1 Tomoyuki Kawamata,1,2 Kumiko Ishida,1 Satoshi Fuseya,1 Takashi Ishida,1 Yuki Sugiyama,1 Mikito Kawamata,1 Satoshi Tanaka1 1Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan ...
Ide S, Kawamata T, Ishida K, Fuseya S, Ishida T, Sugiyama Y, Kawamata M, Tanaka S   +7 more
doaj