Results 41 to 50 of about 1,024,092 (310)

Possible inflammatory pain biomarkers in postamputation pain

Scandinavian Journal of Pain, 2019
Abstract Although chronic pain after amputation is frequent, the underlying mechanisms are still not well understood. It is widely accepted that the pathogenesis of postamputation pain is multifactorial, with both peripheral and central mechanisms playing an essential role.
Buch, Nina Stockfleth, Nikolajsen, Lone, Karlsson, Páll   +2 more
openaire   +2 more sources

Mechanisms of the antiplatelet and analgesic effects of dextromethorphan and its metabolites

Tzu Chi Medical Journal, 2020
Objective: In the present study, we investigated the effects of dextromethorphan (DM) and its metabolites, including dextrorphan (LK2), 3-methoxymorphinan (LK3), and 3-hydroxymorphinan (LK4), on platelet aggregationin vitro and the inflammatory pain ...
Wen-Lin Su, Yu-Ya Weng, Wen-Hsin Huang, Hao-Ai Shui, Tz-Chong Chou   +4 more
doaj   +1 more source

Electrical stimulation of the auricular branch of the vagus nerve potentiates analgesia induced by physical exercise in mice with peripheral inflammation

Frontiers in Integrative Neuroscience, 2023
ObjectiveThis study evaluated the antihyperalgesic and anti-inflammatory effects of percutaneous vagus nerve electrical stimulation (pVNS) associated with physical exercise, i.e., swimming, in mice with peripheral inflammation.MethodsThe pain model was ...
Aline Raulino Dutra, Daiana Cristina Salm, Rafaela Hardt da Silva, Fernanda Tanaka, Daniela Dero Lutdke, Bruna Hoffmann de Oliveira, Rose Lampert, Edsel B. Bittencourt, Gianluca Bianco, Vinícius M. Gadotti, William R. Reed, William R. Reed, Josiel Mileno Mack, Franciane Bobinski, Ari O. O. Moré, Daniel Fernandes Martins   +15 more
doaj   +1 more source

Bee Venom Acupuncture Effects on Pain and Its Mechanisms: An Updated Review

Toxins, 2021
Bee venom (BV) is a complex natural toxin that contains various pharmaceutical compounds. Bee venom acupuncture (BVA), involving a BV injection into a certain acupuncture point, has been utilized to relieve a range of pain conditions.
Soo-Hyun Sung, Gihyun Lee
doaj   +1 more source

N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]

, 2017
N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith, Lawton, Samira K, Prakash, Arun, Schumacher, Mark, Tran, Alphonso, Wilhelmsen, Kevin, Wong, Erika, Xu, Fengyun   +7 more
core   +2 more sources

Rapid S-nitrosylation of actin by NO-generating donors and in inflammatory pain model mice

Molecular Pain, 2011
Background S-Nitrosylation, the reversible post-translational modification of reactive cysteine residues in proteins, has emerged as an important mechanism by which NO acts as a signaling molecule.
Lu Jingshan, Katano Tayo, Uta Daisuke, Furue Hidemasa, Ito Seiji   +4 more
doaj   +1 more source

Neuronal toll like receptor 9 contributes to complete Freund’s adjuvant-induced inflammatory pain in mice

Frontiers in Molecular Neuroscience, 2022
Toll like receptor 9 (TLR9) is a critical sensor for danger-associated molecular patterns (DAMPs) and a crucial marker of non-sterile/sterile inflammation among all TLRs. However, the significance of TLR9 in inflammatory pain remains unclear.
Yu Chen, Hui Chen, Xiao-Chen Li, Wen-Li Mi, Wen-Li Mi, Yu-Xia Chu, Yu-Xia Chu, Yan-Qing Wang, Yan-Qing Wang, Yan-Qing Wang, Qi-Liang Mao-Ying, Qi-Liang Mao-Ying   +11 more
doaj   +1 more source

Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism [PDF]

, 2013
Peer reviewedPublisher ...
Calignano, A, D'Agostino, G, Di Cesare Mannelli, L, Ghelardini, C, Pacini, A, Russo, R, Zanardelli, M   +6 more
core   +4 more sources

The inflammatory process of gout and its treatment. [PDF]

, 2006
Gouty arthritis is a characteristically intense acute inflammatory reaction that erupts in response to articular deposits of monosodium urate (MSU) crystals.
Cronstein, Bruce N, Terkeltaub, Robert
core   +2 more sources

The transient receptor potential channels in rheumatoid arthritis: Need to pay more attention

Frontiers in Immunology, 2023
Rheumatoid arthritis (RA) is characterized by the augment of vascular permeability, increased inflammatory cells infiltration, dysregulated immune cells activation, pannus formation and unbearable pain hyperalgesia.
Mengwen Niu, Feng Zhao, Rui Chen, Ping Li, Liqi Bi   +4 more
doaj   +1 more source