Results 31 to 40 of about 2,640,164 (297)

Inter-strain differences of serotonergic inhibitory pain control in inbred mice [PDF]

, 2010
Background: Descending inhibitory pain control contributes to the endogenous defense against chronic pain and involves noradrenergic and serotonergic systems.
Albuquerque Boris, Irmgard Tegeder, Tegeder Irmgard, Laura Popp, Wijnvoord, Nina, Myrczek, Thekla, Tegeder, Irmgard, Wijnvoord Nina, Popp, Laura, Annett Häussler, Häussler, Annett, Nina Wijnvoord, Myrczek Thekla, Häussler Annett, Popp Laura, Boris Albuquerque, Albuquerque, Boris, Thekla Myrczek   +17 more
core   +1 more source

Antinociceptive Effect of Lodenafil Carbonate in Rodent Models of Inflammatory Pain and Spinal Nerve Ligation-Induced Neuropathic Pain

Journal of Pain Research, 2021
Marcio Carneiro Vieira,1,2 Fernanda Bezerra de Mello Monte,3 Bruno Eduardo Dematte,3 Tadeu Lima Montagnoli,3 Guilherme Carneiro Montes,3 Jaqueline Soares da Silva,3 Rosalia Mendez-Otero,4 Margarete Manhães Trachez,3 Roberto Takashi Sudo,1,3 Gisele
Vieira M C, Monte FBM, Dematte BE, Montagnoli TL, Montes GC, da Silva JS, Mendez-Otero R, Trachez MM, Sudo RT, Zapata-Sudo G   +9 more
doaj  

Phα1β Spider Toxin Reverses Glial Structural Plasticity Upon Peripheral Inflammation

Frontiers in Cellular Neuroscience, 2019
The incoming signals from injured sensory neurons upon peripheral inflammation are processed in the dorsal horn of spinal cord, where glial cells accumulate and play a critical role in initiating allodynia (increased pain in response to light-touch ...
Helia Tenza-Ferrer, Luiz Alexandre Viana Magno, Marco Aurélio Romano-Silva, Marco Aurélio Romano-Silva, Juliana Figueira da Silva, Juliana Figueira da Silva, Marcus Vinicius Gomez, Marcus Vinicius Gomez   +7 more
doaj   +1 more source

Synergistic Antinociceptive Effects of Indomethacin–Pregabalin and Meloxicam–Pregabalin in Paclitaxel-Induced Neuropathic Pain

Biomedicines, 2022
Neuropathic pain is often closely associated with nerve injury or inflammation, and the role of traditional nonsteroidal anti-inflammatory drugs as adjuvants for treating chemotherapy-induced peripheral neuropathic pain remains unclear.
Yurong Ma, Wenwen Liu, Lingzhi Liang, Jiaqi Ye, Chaonan Huang, Tao Zhuang, Guisen Zhang   +6 more
doaj   +1 more source

Identification of Glycine Receptor α3 as a Colchicine-Binding Protein

Frontiers in Pharmacology, 2018
Colchicine (Col) is considered a kind of highly effective alkaloid for preventing and treating acute gout attacks (flares). However, little is known about the underlying mechanism of Col in pain treatment.
Xikun Zhou, Mingbo Wu, Yongmei Xie, Guo-Bo Li, Tao Li, Rou Xie, Kailun Wang, Yige Zhang, Chaoyu Zou, Wenling Wu, Qi Wang, Xiangwei Wang, Ximu Zhang, Jiong Li, Jing Li, Yu-Quan Wei   +15 more
doaj   +1 more source

Effects of different types of neonatal pain on somatosensory and cognitive development in male juvenile rats

Brain and Behavior, 2023
Background Premature infants are inevitably exposed to painful events, including repetitive procedures, inflammation, or mixed stimulation that may induce long‐term behavioral outcomes.
Ru Ling, Yueshu Wang, Wen Zheng, Cuiting Min, Mengying Chen, Dongqing Xia, Xiaonan Li   +6 more
doaj   +1 more source

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

eLife, 2023
Somatosensory information is processed by a complex network of interneurons in the spinal dorsal horn. It has been reported that inhibitory interneurons that express neuropeptide Y (NPY), either permanently or during development, suppress mechanical itch,
Kieran A Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C Dickie, Andrew H Cooper, Andrew M Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I Hughes, Gregory A Weir, John S Riddell, Andrew J Todd   +12 more
doaj   +1 more source

Estimating the burden of disease in chronic pain with and without neuropathic characteristics: does the choice between the EQ-5D and SF-6D matter? [PDF]

, 2014
The EQ-5D and Short Form (SF)12 are widely used generic health-related quality of life (HRQoL) questionnaires. They can be used to derive health utility index scores, on a scale where 0 is equivalent to death and 1 represents full health, with scores ...
Serpell, MG, Lawson, Kenny D. (R18539), Afolabi, Ebenezer, Afolabi, E, Smith, BH, Torrance, N, Bennett, MI, Dunn, KM, Smith, Blair H., Lawson, Kenny D., Smith, Blair H.; id_orcid, Dunn, Kate M., Bennett, Michael I., Lawson, Kenny, Torrance, Nicola, Serpell, Michael G., Lawson, KD   +16 more
core   +1 more source

Pain and inflammatory bowel disease [PDF]

Inflammatory Bowel Diseases, 2009
Abdominal pain is a common symptom of inflammatory bowel disease (IBD: Crohn's disease, ulcerative colitis). Pain may arise from different mechanisms, which can include partial blockage and gut distention as well as severe intestinal inflammation. A majority of patients suffering from acute flares of IBD will experience pain, which will typically ...
Klaus, Bielefeldt, Brian, Davis, David G, Binion   +2 more
openaire   +2 more sources

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source