Molecular Pain, 2011 Oncostatin M (OSM) is a member of the interleukin-6 cytokine family and regulates eg. gene activation, cell survival, proliferation and differentiation. OSM binds to a receptor complex consisting of the ubiquitously expressed signal transducer gp130 and ...
Langeslag Michiel +5 more
doaj +1 more source
Preclinical Assessment of Inflammatory Pain [PDF]
CNS Neuroscience & Therapeutics, 2015 SummaryWhile acute inflammation is a natural physiological response to tissue injury or infection, chronic inflammation is maladaptive and engenders a considerable amount of adverse pain. The chemical mediators responsible for tissue inflammation act on nociceptive nerve endings to lower neuronal excitation threshold and sensitize afferent firing rate ...
Milind M, Muley +2 more
openaire +2 more sources
Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. [PDF]
, 2015 Peripheral nerve injury can trigger neuropathic pain in adults but not in infants; indeed, for unknown reasons, neuropathic pain is rare before adolescence. We show here that the absence of neuropathic pain response in infant male rats and mice following
Ji, RR +9 more
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The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]
, 1964 1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
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The British Journal of Radiology, 1991 A 57-year-old male was admitted as an emergency with a 3 day history of thirst, frequency and severe low back pain radiating to his right flank for 24 h. He was apyrexial and examination was normal. An elevated plasma glucose confirmed late onset diabetes. Urinalysis did not show any evidence of infection.
S A, Renowden, M W, Hayward
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The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation [PDF]
, 2005 Therapies directed against tumour necrosis factor (TNF) are effective for the treatment of rheumatoid arthritis and reduce pain scores in this condition.
Inglis, JJ +11 more
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Diclofenac solution (Pennsaid) in the management of osteoarthritis of the knee : Patient implications [PDF]
, 2009 Topical diclofenac sodium (pennsaid) is a non-steroidal-anti- inflammatory drug that is used to manage the recurrent pain and symptoms of osteoarthritis of the knee. Pennsaid is applied topically, absorbed cutaneously and concentrates locally at the site
Banning, M
core +6 more sources
R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids [PDF]
, 2010 Background: R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear.
Geisslinger, Gerd +45 more
core +1 more source
Rab7 - A novel redox target that modulates inflammatory pain processing
, 2022 S.1354-1365Chronic pain is accompanied by production of reactive oxygen species (ROS) in various cells that are important for nociceptive processing.
Möser, C.V. +15 more
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Quality of life and chronic pain four years after gastrointestinal surgery [PDF]
, 2006 PURPOSE: Little is known about the prevalence of chronic postsurgical pain after gastrointestinal surgery. This study was designed to assess the prevalence of chronic pain and quality of life in a cohort of patients who underwent surgery for benign and ...
Krukowski, Zygmunt H., Bruce, Julie
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